Type-2-diabetes

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Unknown (37891)
Transcriptomics (8249)
Genomics (3361)
Proteomics (512)
Metabolomics (90)
Genomic (59)
Methylation profiling (59)
Other (40)
Models (24)
Clinical (19)
Multiomics (13)

Organisms

Homo sapiens (5547)
Mus musculus (3136)
Rattus norvegicus (307)
Drosophila melanogaster (194)
Danio rerio (52)
Gallus gallus (36)
Sus scrofa (34)
Arabidopsis thaliana (33)
Caenorhabditis elegans (30)
Saccharomyces cerevisiae (27)
Bos taurus (26)
Canis lupus familiaris (25)
synthetic construct (20)
Zea mays (16)
Macaca mulatta (15)
Candida albicans (10)
Chlorocebus aethiops (6)
Solanum lycopersicum (6)
Escherichia coli (6)
Leishmania donovani (5)
Pan troglodytes (5)
mixed sample (5)
Cricetulus griseus (5)
Oncorhynchus mykiss (5)
Felis catus (5)
Chlorocebus sabaeus (4)
Campylobacter jejuni (4)
Oryza sativa (4)
Mus sp. (2)
Rattus (1)

Organisms

Homo sapiens (669)
Mus musculus (640)
Rattus norvegicus (96)
human gut metagenome (22)
mouse gut metagenome (13)
Danio rerio (7)
feces metagenome (5)
unidentified (5)
Arvicanthis niloticus (4)
Drosophila melanogaster (4)
human feces metagenome (4)
rat gut metagenome (3)
Sus scrofa (3)
Macaca fascicularis (2)
Mus musculus musculus (2)
Caenorhabditis elegans (2)
Felis catus (2)
gut metagenome (2)
Crocosmia x crocosmiiflora (1)
whole organism metagenome (1)
Arcanobacterium haemolyticum (1)
Microcebus murinus (1)
Arctium lappa (1)
Prevotella (1)
Actinoplanes sp. SE50/110 (1)
Actinoplanes (1)
organismal metagenomes (1)
Rattus (1)
Latilactobacillus sakei (1)
Burkholderia pseudomallei (1)

Repository

biostudies-arrayexpress (8331)
ENA (2045)
geo (1154)
pride (326)
EGA (185)
MetaboLights (81)
MassIVE (70)
dbGaP (59)
iProX (43)
PeptideAtlas (26)
BioModels (24)
jPOST (14)
NODE (12)
PanoramaPublic (11)
ExpressionAtlas (9)
EVA (5)
GNPS (5)
MetabolomicsWorkbench (4)
GPMDB (2)
PAXDB (1)

Tissue

Cell culture (44)
Liver (42)
Blood plasma (29)
Hepatocyte (16)
Kidney (15)
Skeletal muscle (15)
Pancreatic islet (14)
Brain (13)
Heart (13)
Type B pancreatic cell (13)
Blood serum (12)
Others (11)
Pancreas (11)
Saliva (10)
Permanent cell line cell (10)
Blood cell (9)
Feces (8)
Adipose tissue (7)
Epithelial cell (7)
Islet of Langerhans (7)
Fat cell (6)
Macrophage (6)
White adipose tissue (6)
Blood (5)
Pancreatic islet cell (5)
Blood (4)
Plasma Non-glyco (3)
Sternohyoid (1)
Diaphragm (1)
Cell line (1)

Disease

Type 2 diabetes mellitus (181)
Normal (34)
Breast cancer (10)
Diabetes mellitus (6)
Prostate cancer (6)
Adenocarcinoma (6)
Type II diabetes mellitus (4)
Colorectal carcinoma (4)
Colorectal adenocarcinoma (4)
Colon cancer (4)
Papillary thyroid carcinoma (3)
Glioblastoma (3)
Breast carcinoma (3)
Rheumatoid arthritis (2)
Cancer (2)
Murine hereditary hemochromatosis (2)
Gastric cancer (2)
Osteosarcoma (2)
Hepatocellular carcinoma (2)
Carcinoma (2)
Neuroblastoma (2)
Type 2 diabetes, obesity (1)
Type 2 diabetes (1)
Pre-diabetes control (1)
Normoglycemic control (1)
XCGD (1)
Huntington's disease mouse model (1)
Familial combined hyperlipidemia (1)
GIP-dependent Cushing's syndrome (1)
Integrated HPV16 only (1)

Technology Type

Mass Spectrometry (330)
Shotgun proteomics (162)
Bottom-up proteomics (61)
Mass spectrometry (59)
Data-dependent acquisition (38)
Data-independent acquisition (37)
Top-down proteomics (29)
SWATH MS (20)
Mass spectrometry assay (18)
Affinity purification coupled with mass spectrometry proteomics (14)
Unknown, Affymetrix 500K (11)
Gel-based experiment (7)
Affymetrix 500K, unknown (6)
Illumina HiSeq 2000 (4)
NMR spectroscopy (4)
ESI (4)
ILLUMINA, Illumina Genome Analyzer IIx, Illumina HiSeq 2500 (1)
Illumina HumanCoreExome-12v1-0 (1)
ILLUMINA, NextSeq 500 (1)
ILLUMINA, Illumina HiSeq 2500 (1)
HiSeq X Ten, ILLUMINA (1)
AB 5500xl Genetic Analyzer (1)
ZCall, Illumina HumanExome-12v1_A-GenCall (1)
Illumina (1)
Illumina 1.2M, Affymetrix 6.0, Affymetrix 6.0 - CHIAMO (1)
Illumina Genome Analyzer II, Illumina HiSeq 2000 (1)
Illumina HumanExome-12v1_A-GenCall, zCall, GenoSNP, - Illuminus (1)
Illumina HiSeq 2000, ILLUMINA (1)
NMR spectroscopy assay (1)
EI (1)

Instrument Platform

Illumina NovaSeq 6000 (303)
NextSeq 500 (210)
Illumina HiSeq 2500 (136)
Illumina HiSeq 4000 (127)
Illumina HiSeq 2000 (102)
NextSeq 550 (50)
Illumina NovaSeq X (37)
NextSeq 2000 (31)
Illumina MiSeq (20)
Illumina HiSeq 1500 (20)
Illumina Genome Analyzer IIx (14)
Illumina Genome Analyzer II (13)
DNBSEQ-G400 (13)
NA (11)
Illumina HiSeq 3000 (9)
Element AVITI (8)
Ion Torrent Proton (7)
GenePix 4000B [Axon Instruments] (6)
10x Genomics Chromium Controller (6)
Scanning hardware (5)
Illumina HiSeq 1000 (5)
Agilent 2100 Bioanalyzer (4)
Agilent G2565AA and G2565BA Microarray Scanner (4)
GenePix Professional 4200A [Axon Instruments] (4)
Affymetrix Fluidics Station 400 (4)
Axon GenePix 4000B scanning hardware (4)
DNBSEQ-T7 (4)
BGISEQ-500 (4)
HiSeq X Ten (4)
10x Chromium Controller (3)

Publication Date

2014 (1215)
2013 (1122)
2015 (1114)
2012 (925)
2016 (761)
2010 (738)
2011 (718)
2025 (401)
2024 (323)
2026 (320)
2023 (307)
2008 (295)
2009 (293)
2022 (291)
2021 (287)
2020 (243)
2019 (192)
2018 (172)
2017 (146)
2007 (119)
2006 (44)
2005 (39)
2004 (24)
2003 (2)
2002 (2)

UNIPROT ID/AC

P07195 (15)
P01308 (6)
P35568 (4)
P06213 (4)
P42345 (3)
P14672 (3)
P62753 (2)
Q6R327 (2)
Q8N122 (2)
O60343 (2)
P18510 (2)
P23443 (2)
P01584 (2)
P31751 (2)
P10515 (1)
P01275 (1)
P13678 (1)
Q96G03 (1)
P54840 (1)
Q16822 (1)
Q15181 (1)
P17858 (1)
P35557 (1)
O75390 (1)
P11168 (1)
P16118 (1)
P05062 (1)
P00338 (1)
O00330 (1)
P09622 (1)

ENSEMBL ID

ENSMUSG00000027651 (12)
ENSMUSP00000141097 (10)
ENSMUSG00000021039 (9)
ENSG00000170477 (7)
ENSMUSG00000090272 (6)
ENSMUSP00000106991 (6)
ENSMUSP00000111587 (6)
ENSMUSG00000098557 (5)
ENSG00000229353 (3)
ENSG00000147251 (1)
ENSMUSP00000141542 (1)

CHEBI ID

CHEBI:30769 (21)
CHEBI:32816 (15)
CHEBI:16027 (14)
CHEBI:17234 (11)
CHEBI:30744 (8)
CHEBI:4167 (8)
CHEBI:6801 (7)
CHEBI:36080 (4)
CHEBI:52217 (2)
CHEBI:18357 (2)
CHEBI:422 (2)
CHEBI:4170 (2)
CHEBI:15713 (2)
CHEBI:16077 (2)
CHEBI:28087 (2)
CHEBI:15377 (2)
CHEBI:24636 (2)
CHEBI:15351 (2)
CHEBI:15346 (2)
CHEBI:29052 (2)
CHEBI:17659 (2)
CHEBI:18066 (2)
CHEBI:15996 (2)
CHEBI:17552 (2)
CHEBI:28602 (2)
CHEBI:17835 (2)
CHEBI:17794 (2)
CHEBI:16001 (2)
CHEBI:16905 (2)
CHEBI:15422 (2)

Metabolite Name

Uracil (15)
Hypoxanthine (15)
Palmitic acid (14)
Adenine (14)
L-Serine (14)
Creatine (14)
Uridine (13)
L-Threonine (12)
L-Glutamine (12)
Uric acid (12)
Xanthine (12)
L-Tyrosine (12)
Thymine (11)
L-Phenylalanine (11)
Glycine (10)
L-Arginine (10)
Taurine (10)
Citric acid (10)
Adenosine (10)
Guanosine (10)
L-Isoleucine (10)
L-Proline (9)
Succinic acid (9)
Cholesterol (9)
L-Glutamic acid (9)
Spermidine (9)
Cytosine (9)
Linoleic acid (9)
L-Tryptophan (9)
Isoleucine (9)

First Public Date

2024 (296)
2025 (218)
2014 (209)
2026 (208)
2023 (193)
2022 (167)
2021 (163)
2020 (144)
2019 (121)
2017 (77)
2018 (72)
2015 (60)
2016 (59)
2013 (58)

Modelling Approach

Ordinary differential equation model (20)
Physiologically based pharmacokinetic model (4)
Logical model (1)
Metabolic network (1)

Study status

Recruiting (10)
Active, not recruiting (3)
Not yet recruiting (3)
Completed (3)

Lab affiliation

The University of Sydney (4)
The University of Sydney, Australia (4)
Department of Fundamental Neurosciences, Rue du Bugnon 9, 1005, Lausanne (3)
Department of Immunotechnology, Lund University (3)
Research Unit for Molecular Medicine, Department of Clinical Medicine, Aarhus University, Denmark (3)
University of Malaya (3)
Department of Biochemistry and Molecular Biology School of Medicine, Oregon Health & Science University 3181 SW Sam Jackson Park Road Portland, OR 97239, USA (2)
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States (2)
Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology (2)
Head of Proteomics (2)
Howard Hughes Medical Institute Beth Israel Deaconess Medical Center Harvard Medical School (2)
Inserm U1016, Institut Cochin, 24 rue du Faubourg Saint-Jacques, 75014 PARIS, FRANCE. (2)
Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Auf´m Hennekamp 65, 40225 Düsseldorf, Germany (2)
Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia (2)
OncoProteomics Laboratory, Dept of Medical Oncology, Amsterdam University Medical Centers, Amsterdam, The Netherlands (2)
Professor of biochemistry, deputy head of department Biomarker Research Group - group leader Department of Biochemistry and Molecular Biology Faculty of Medicine University of Debrecen 4032 Debrecen, Egyetem ter 1. (2)
Proteomics Core Facility and Research Group Proteomics, CEITEC-MU, Masaryk University, Brno, Czech Republic (2)
Proteomics and Metabolomics Core Facility, Biomedical Research Institute, Seoul National University Hospital (2)
School of Life and Environmental Sciences, Charles Perkins Centre, Faculty of Science, The University of Sydney, NSW, Australia. (2)
THE INSTITUTE OF BIOPHYSICS, CAS (2)
The University of Melbourne (2)
University of Bergen (2)
Wellcome Centre for Cell-matrix biology, University of Manchester, UK. (2)
Wellcome Trust MRC Institute of Metabolic Science (2)
1 Health Management Center, the Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China; 2 Department of Cardiology, the Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China; (1)
1 Key Laboratory of Protein and Peptide Pharmaceuticals & Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China 2 University of Chinese Academy of Sciences, Beijing 100049, China (1)
1) Department Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; 2) Institute for Bioanalysis, University of Applied Science Coburg, Coburg, Germany (1)
1. Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Dortmund, Germany 2. Pediatric Neurology, University Hospital Essen, University of Duisburg-Essen, Faculty of Medicine, Essen, Germany (1)
1.Semmelweis University, Department of Pharmacology and Pharmacotherapy, Budapest, Hungary. 2.Pharmahungary Group, Szeged, Hungary (1)
1Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia. 2Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria 3800, Australia. (1)

Keyword

Diet (3)
Plant protein (2)
Animal protein (2)
Polygenic risk score (1)
Postprandial Glucose (1)
Postprandial Insulin (1)
Satiety (1)
NOD2 ligands (1)
21+ years old (1)
Address (1)
Amputation (1)
Area (1)
Arm (1)
Atheroscleroses (1)
Atherosclerotic (1)
Bariatrics (1)
Behavior Conditioning Therapy (1)
Behavior Modification (1)
Behavior Therapy (1)
Behavior Treatment (1)
Behavior or Life Style Modifications (1)
Behavioral (1)
Behavioral Conditioning Therapy (1)
Behavioral Modification (1)
Behavioral Therapy (1)
Behavioral Treatment (1)
Beta Cell (1)
Blood Pressure, High (1)
Blood Vessels (1)
Body Weight decreased (1)

IsPrivate

False (24)

Model Flag

Non Kinetic (2)

Classification

bacteria (6)

Modification

Not available (3)
15.994915 (2)
-17.026549 (1)
42.010565 (1)
56.026215 (1)
57.021464 (1)
59.036279 (1)

Study type

Transcription profiling by array (4722)
RNA-seq of coding RNA (1186)
ChIP-seq (821)
RNA-seq of coding RNA from single cells (214)
Other (179)
ChIP-chip by tiling array (152)
RNA-seq of non coding RNA (134)
Methylation profiling by array (104)
Methylation profiling by high throughput sequencing (98)
Comparative genomic hybridization by array (86)
Unknown experiment type (75)
RNA-seq of total RNA (69)
DNA-seq (40)
Cell line - High-throughput sequencing (39)
MicroRNA profiling by array (38)
ChIP-chip by array (37)
Transcription profiling by RT-PCR (29)
ATAC-seq (28)
Genotyping by array (27)
Transcription profiling by tiling array (24)
Animal - High-throughput sequencing (17)
Human - High-throughput sequencing (15)
Proteomic profiling by array (15)
Transcription profiling by SAGE (14)
Cell line - One-color microarray (13)
RNAi profiling by array (12)
RIP-seq (10)
MicroRNA profiling by high throughput sequencing (8)
CUT&RUN (8)
Baseline (7)

Release Date

2022 (4765)
2025 (4515)
2023 (4113)
2021 (4072)
2024 (3538)
2020 (3196)
2019 (2586)
2015 (2394)
2018 (2339)
2016 (2295)
2014 (2266)
2017 (1939)
2013 (1890)
2012 (1459)
2011 (1280)
2010 (1209)
2026 (749)
2009 (663)
2008 (501)
2007 (208)
2006 (87)
2005 (67)
2004 (42)
2003 (15)
2000 (13)
2002 (9)
2001 (8)
1998 (2)
1999 (1)

Location

United States (7)
China (2)
Canada (2)
Netherlands (2)
Finland (1)
Germany (1)
Belgium (1)
Australia (1)
United Kingdom (1)

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A metabolomic study of urinary changes in type 2 diabetes in human compared to the control group

Type 2 diabetes mellitus is the result of a combination of impaired insulin secretion with reduced insulin sensitivity of target tissues. There are an estimated 150 million affected individuals worldwide, of whom a large proportion remains undiagnosed because of a lack of specific symptoms early in ...

2012-02-14 | MTBLS1 | MetaboLights

EFO: In preparation - Early Metabolic Predictors of Type 2 Diabetes Mellitus in Normoglycemic Adults: Insights from Six-Year Prospective Cohort Study

INTRODUCTION: Type 2 Diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia, often preceded by latent metabolic disruptions. Early detection of metabolic alterations can facilitate timely intervention to delay or prevent T2DM onset. Metaboli...

2025-08-04 | MTBLS10965 | MetaboLights

Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type-2 diabetes

In this study we explored a unique cohort of 43 samples to build a map of metabolites varying in T2D across five different tissues (subcutaneous adipose tissue, liver, pancreatic islets, skeletal muscle and blood serum). The samples originate from the Excellence in Diabetes biobank (EXODIAB) in Swed...

2018-10-08 | MTBLS690 | MetaboLights

Celery (Apium graveolens L.) Juice Fermented with Lactiplantibacillus plantarum NCU116 Mitigates Type 2 Diabetes in Mice: Mechanistic Insights from Gut Microbiota and Metabolomics

This study aimed to investigate the metabolic effects of fermented celery juice (FCJ) and non-fermented celery juice (NFCJ) in a mouse model of type 2 diabetes. Fresh celery juice was fermented with Lactiplantibacillus plantarum NCU116 under controlled conditions. Male C57BL/6J mice were divided ...

2025-08-06 | MTBLS12826 | MetaboLights

FFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes

The function of islet macrophages is poorly understood. They promote glucose-stimulated insulin secretion (GSIS) in lean mice, however, the underlying mechanism has remained unclear. We show that activation of the free fatty acid receptor FFAR4 on islet macrophages leads to interleukin-6 (IL-6) r...

2026-08-19 | MTBLS12317 | MetaboLights

Integration of whole-body [18F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes

Alteration of various metabolites has been linked to type 2 diabetes (T2D) and insulin resistance. However, identifying significant associations between metabolites and tissue-specific phenotypes requires a multi-omics approach. In a cohort of 42 subjects with different levels of glucose tolerance (...

2020-01-06 | MTBLS1051 | MetaboLights

Integrated Multi-omics Analysis Identifies Diagnostic Biomarkers for Acute Coronary Syndrome in Type 2 Diabetes Mellitus Patients

Biomarkers for the early identification of acute coronary syndrome (ACS) risk remain inadequately investigated, particularly in patients with type 2 diabetes mellitus (T2DM), for whom timely clinical intervention may substantially enhance prognostic outcomes. The gut microbiota and serum metaboli...

2026-03-19 | MTBLS14087 | MetaboLights

Salivary Multi-omics Characterization and Staging Diagnostic Model for Type 2 Diabetes with Different Stages of Periodontitis

Background: This study aims to comprehensively characterize the dynamic succession of the salivary microbiome and metabolic reprogramming in type 2 diabetes mellitus (T2DM) patients across progressive stages of periodontitis (Stage I–IV) using an integrated multi-omics approach. We specifica...

2026-05-20 | MTBLS13827 | MetaboLights

Disorders of gut microbiota and fecal-serum metabolic patterns are associated with pulmonary tuberculosis and pulmonary tuberculosis co-morbid type 2 diabetes mellitus

BACKGROUND: Pulmonary tuberculosis (PTB) and diabetes mellitus (DM) are prevalent chronic diseases with substantial implications for human health. DM patients are more susceptible to PTB, which exacerbates diabetes-related complications. However, the complex molecular mechanisms ...

2023-12-15 | MTBLS8729 | MetaboLights

Metabolomics Linking Air Pollution, Obesity and Type 2 Diabetes

Not available

ORGANISM(S): Homo sapiens

ST000909 | MetabolomicsWorkbench

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