Sort   by:  
 Page size 
ProteomicsTyrosine phosphorylation of IQGAP1 in the MET pathway
Mass spectrometry was used to determine that cellular IQGAP1 and IQGAP2 proteins are phosphorylated at multiple tyrosine residues upon sodium orthovanadate treatment.
ORGANISM(S): Human 
MSV000086088 | MassIVE
ProteomicsEvaluation of phospho-tyrosine antibodies for label-free phosphoproteomics
In the past decade multiple tyrosine kinase inhibitors (TKIs) have been implemented in standard treatment regimens for patients with cancer. Unfortunately the majority of patients develops resistance to these drugs. Reliable tools for analysis of pharmacodynamic effects and drug resistance mechanism...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080270 | MassIVE
ProteomicsBead-based kinase phosphorylation profiling identifies SRC as a therapeutic target in glioblastoma
Here we describe a bead-based method capable of profiling tyrosine kinase phosphorylations in a multiplexed, high-throughput and low-cost manner. This approach allows for the discovery of tyrosine kinase-activating events, even when the DNA sequence is wild-type. In an effort to pilot the establishm...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-13808 | biostudies-arrayexpress
ProteomicsTyrosine phosphoproteomics of patient-derived xenografts reveals ephrin type-B receptor 4 tyrosine kinase as novel therapeutic target in pancreatic cancer
Pancreatic ductal adenocarcinoma is a recalcitrant tumor with minimal response to conventional chemotherapeutic approaches. Oncogenic signaling by activated tyrosine kinases has been implicated in cancers resulting in activation of diverse effector signaling pathways. Thus, discovery of aberrantly a...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-05-24 | PXD021729 | Pride
Receptor tyrosine kinase Ptyr Pdx Signaling Cancer 
UnknownIdentification and specific localization of tyrosine-phosphorylated proteins in Trypanosoma brucei.
Not available
S-EPMC2669198 | biostudies-literature
ProteomicsTyrosine phosphorylation of IQGAP1 in the MET pathway
Mass spectrometry was used to determine IQGAP1 is a substrate of MET and c-Src, and is phosphorylated exclusively on Tyr-1510 under conditions with enhanced MET or c-Src cellular activity.
ORGANISM(S): Human 
MSV000086089 | MassIVE
GenomicsRole of Polycomb group proteins in the DNA damage response – a reassessment
We have investigated whether components of Polycomb repressive complex 1 (PRC1) are recruited to double-strand breaks (DSBs) generated by inducible expression of the AsiSI restriction enzyme in normal human fibroblasts. Using chromatin immunoprecipitation and deep sequencing (ChIP-seq), which detec...
ORGANISM(S): Homo sapiens 
2014-07-06 | E-GEOD-55605 | biostudies-arrayexpress
TranscriptomicsNon-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2
A synthetic analog of sphingosine named FTY720 (Fingolimod), phosphorylated by sphingosine kinase-2, interacts with sphingosine-1-phosphate (S1P) receptors expressed on various cells. FTY720 suppresses the disease activity of multiple sclerosis (MS) chiefly by inhibiting S1P-dependent egress of auto...
ORGANISM(S): Homo sapiens 
2011-04-16 | E-GEOD-28642 | biostudies-arrayexpress
Proteomics012819 Hawse phospho Tyrosine dataset
In order to determine early signaling in T-cell activations we have profiled proteins that contain phosphorylated Tyrosine residues.
ORGANISM(S): Mus musculus (Mouse) 
2020-05-04 | PXD017871 | Pride
T-cell Phospho tyrosine 
UnknownIncorporation of Phosphorylated Tyrosine into Proteins: In Vitro Translation and Study of Phosphorylated IκB-α and Its Interaction with NF-κB.
Not available
S-EPMC5901656 | biostudies-literature
Sort   by:  
 Page size