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ProteomicsProtein expression and identification of Tyrp1 Mutant Variants Associated with OCA3 form of albinism.
Oculocutaneous albinism type 3 (OCA3) is an autosomal recessive disorder caused by mutations in the TYRP1 gene. Tyrosinase-related protein 1 (Tyrp1) is involved in eumelanin synthesis, catalyzing the oxidation of 5,6-dihydroxyindole-2-carboxylic acid oxidase (DHICA) to 5,6-indolequinone-2-carboxylic...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2023-06-12 | PXD034893 | Pride
Oca3 Albinism Tyrp1 
ProteomicsProtein expression and identification of Tyrp1 Mutant Variants Associated with OCA3 form of albinism.
Oculocutaneous albinism type 3 (OCA3) is an autosomal recessive disorder caused by mutations in the TYRP1 gene. Tyrosinase-related protein 1 (Tyrp1) is involved in eumelanin synthesis, catalyzing the oxidation of 5,6-dihydroxyindole-2-carboxylic acid oxidase (DHICA) to 5,6-indolequinone-2-carboxylic...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2023-06-12 | PXD034892 | Pride
Oca3 Albinism Tyrp1 
TranscriptomicsTYRP1 knock-down in human melanoma cell line (501Mel)
Efficient TYRP1 knock-down (KD) have been performed in human melanoma cell line expressing a high level of TYRP1 mRNA and protein in order to identify the molecular pathway explaining the decrease of cell proliferation in TYRP1 KD cells.
ORGANISM(S): Homo sapiens 
2017-07-01 | GSE70561 | GEO
GenomicsA noncoding function of TYRP1 mRNA promotes melanoma growth
Competition among RNAs to bind miRNA is proposed to influence biological systems. However, the role of this competition in disease onset is unclear. Here, we report that TYRP1 mRNA, in addition to encoding tyrosinase-related protein 1 (TYRP1), indirectly governs cell proliferation by sequestering mi...
ORGANISM(S): Homo sapiens 
2017-08-08 | GSE95589 | GEO
GenomicsTyrp1 is the mendelian determinant of the Axolotl (Ambystoma mexicanum) copper mutant
Tyrp1 is the mendelian determinant of the Axolotl (Ambystoma mexicanum) copper mutant
PRJNA1120065 | ENA
GenomicsA novel TYRP1 variant is associated with liver and tan coat colour in Lancashire Heelers
A novel TYRP1 variant is associated with liver and tan coat colour in Lancashire Heelers
PRJEB32213 | ENA
GenomicsSsc-miR-221-3p regulates melanin production in Xiang pigs melanocytes by targeting the TYRP1 gene
The TYRP1 gene can affect melanogenesis in melanocytes of the Xiang pigs, and ssc-miR-221-3p targets the TYRP1 gene to affect melanogenesis in melanocytes of the Xiang pigs.
ORGANISM(S): Sus scrofa 
2022-11-30 | GSE218870 | GEO
UnknownSNPs at miR-155 binding sites of TYRP1 explain discrepancy between mRNA and protein and refine TYRP1 prognostic value in melanoma.
Not available
S-EPMC4647532 | biostudies-literature
TranscriptomicsTyrp1 is the mendelian determinant of the Axolotl (Ambystoma mexicanum) copper mutant
Several dozen Mendelian mutants have been discovered in axolotl (Ambystoma mexicanum) populations, including several that affect pigmentation. Four pigment mutants have been described in the scientific literature and genes for three of these have been identified. Here we report on copper, a Mendelia...
ORGANISM(S): Ambystoma mexicanum 
2024-10-22 | GSE269079 | GEO
UnknownBiophysical Compatibility of a Heterotrimeric Tyrosinase-TYRP1-TYRP2 Metalloenzyme Complex.
Not available
S-EPMC8114058 | biostudies-literature
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