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ProteomicsIMPAIRED CHONDROCYTE U3 SNORNA EXPRESSION IN OSTEOARTHRITIS AND ITS IMPACT ON THE CHONDROCYTE’S PROTEIN TRANSLATION APARATUS
Osteoarthritis (OA) is a chronic debilitating joint disease which is strongly associated with ageing. OA involves pathological cellular processes in all joint structures and affects articular cartilage integrity, leading to dysfunctional joint articulation. The biomolecular processes that catalyze t...
ORGANISM(S): Homo sapiens (Human) 
2020-08-21 | PXD017253 | Pride
Osteoarthritis Snorna Translation 
ProteomicsAtypical U3 snoRNA Suppresses the Process of Pterygia through Modulating 18S Ribosomal RNA Synthesis
Ribosome biosynthesis plays a crucial role in regulating protein translation and is essential for cell growth and development in physiological progress. The progression and recurrence of Pterygia mainly occur due to the abnormal proliferation and migration of stromal Pterygia fibroblasts. Small nucl...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030801 | Pride
Pterygium U3 snorna 47s rrna 18s rrna 5' ets Ribosome biosynthesis 
TranscriptomicsHigh-throughput measurements of fitness effects of mutations in the yeast U3 snoRNA
We used a molecular barcoding approach to quantify the fitness of ~60,000 randomly mutated variants of the Saccharomyces cerevisiae U3 snoRNA (the data were further used to calculate a map of intragenic epistatic interactions within this RNA molecule, as descibed in Puchta et al. 2016) We generated ...
ORGANISM(S): Saccharomyces cerevisiae 
2016-02-09 | E-GEOD-77709 | biostudies-arrayexpress
GenomicsGene expression differences between control and overexpressing U3 snoRNA in HPF
Gene expression differences between control and overexpressing U3 snoRNA in HPF
PRJNA794743 | ENA
TranscriptomicsSIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing [CLIP-Seq]
SIRT7 is an NAD+-dependent protein deacetylase with important roles in ribosome biogenesis and cell proliferation. Previous studies have established that SIRT7 is associated with RNA polymerase I, interacts with pre-rRNA and promotes rRNA synthesis. Here we show that SIRT7 is also associated with sn...
ORGANISM(S): Homo sapiens 
2016-01-07 | E-GEOD-76578 | biostudies-arrayexpress
UnknownInteraction of the U3-55k protein with U3 snoRNA is mediated by the box B/C motif of U3 and the WD repeats of U3-55k.
Not available
S-EPMC110750 | biostudies-literature
GenomicsSnoRNA:U3:9B is required for the activation of immune response genes in Drosophila melanogaster [ATAC-Seq]
SnoRNA:U3:9B is required for the activation of immune response genes in Drosophila melanogaster [ATAC-Seq]
PRJNA1186160 | ENA
UnknownImpaired chondrocyte U3 snoRNA expression in osteoarthritis impacts the chondrocyte protein translation apparatus.
Not available
S-EPMC7417995 | biostudies-literature
UnknownAtypical U3 snoRNA Suppresses the Process of Pterygium Through Modulating 18S Ribosomal RNA Synthesis.
Not available
S-EPMC9055567 | biostudies-literature
GenomicsSnoRNA:U3:9B is required for the activation of immune response genes in Drosophila melanogaster [RNA-Seq]
SnoRNA:U3:9B is required for the activation of immune response genes in Drosophila melanogaster [RNA-Seq]
PRJNA1183813 | ENA
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