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TranscriptomicsGenome wide mapping of effects of U6atac knockdown on pre-mRNA splicing
This project looks into experimentally identifying all minor introns by knocking down the minor spliceosome's catalytic snRNP, U6atac. Knockdown of U6atac by antisense morpholino followed by examining mRNA splicing by RNA-seq
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-48263 | biostudies-arrayexpress
TranscriptomicsDrosophila U6atac snRNA mutant
A Drosophila line (l(2)k01105) with a P-element insertion in U6atac snRNA, an essential component of the U12-type spliceosome, was used to investigate the impact of disrupted U12-dependent splicing during larval development. A custom-designed exon array was used to study the expression of genes cont...
ORGANISM(S): Drosophila melanogaster 
2010-10-11 | GSE24148 | GEO
TranscriptomicsDrosophila U6atac snRNA mutant
A Drosophila line (l(2)k01105) with a P-element insertion in U6atac snRNA, an essential component of the U12-type spliceosome, was used to investigate the impact of disrupted U12-dependent splicing during larval development. A custom-designed exon array was used to study the expression of genes cont...
ORGANISM(S): Drosophila melanogaster 
2010-10-11 | E-GEOD-24148 | biostudies-arrayexpress
UnknownMinor introns are embedded molecular switches regulated by highly unstable U6atac snRNA.
Not available
S-EPMC3728624 | biostudies-literature
GenomicsDrosophila melanogaster
Drosophila U6atac snRNA mutant
PRJNA130027 | ENA
GenomicsATAC-seq from WCM154 prostate cancer cell line 94h after U6atac knockdown
U6atac, a minor spliceosome component, is a crucial regulator of genome stability in cancer. Here we investigate chromatin accessibility profiles in the WCM154 prostate cancer cell line 96h following U6atac knockdown.
ORGANISM(S): Homo sapiens 
2026-10-05 | GSE348827 | GEO
TranscriptomicsGenome wide mapping of effects of U6atac knockdown on pre-mRNA splicing
This project looks into experimentally identifying all minor introns by knocking down the minor spliceosome's catalytic snRNP, U6atac.
ORGANISM(S): Homo sapiens 
2013-08-01 | GSE48263 | GEO
ProteomicsMinor intron splicing efficiency increases with the development of lethal prostate cancer
Minor intron-containing genes (MIGs) are crucial cell cycle regulators and are essential for cell survival. Thus, we explored whether MIGs play a role in cancer progression and cancer therapy resistance. Here we show that MIG-expression segregates sensitive and resistant prostate cancer cells from e...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD026949 | Pride
Minor spliceosome Lineage plasticity Minor intron genes U6atac Prostate cancer 
GenomicsHomo sapiens
Genome wide mapping of effects of U6atac knockdown on pre-mRNA splicing
PRJNA209423 | ENA
ProteomicsThe Role of Extracellular Spliceosomal snRNAs in Communication of Ovarian Cancer Cells
Exogenous signals from drug-stressed cancer cells accelerate the proliferation of neighboring tumor cells and promote them to acquire a more aggressive phenotype. We have recently found an exciting phenomenon: drug-stressed cancer cells secrete various components of the spliceosome: proteins and a n...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD027950 | Pride
Ovarian cancer Small nuclear rna Proteomics Spliceososme 
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