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ProteomicsUAG suppression in HEK293T cells
HEK293T cells, stably transfected with pyrrolysine UAG suppressor tRNA and aminoacyl tRNA synthetase, for the co-translational incorporation of Boc-protected lysine.
ORGANISM(S): Homo sapiens (Human) 
2020-02-24 | PXD016728 | Pride
Human Uag suppressor trna 
ProteomicsN-terminal amino acid identification using targeted mass spectrometry
Using engineered initiator tRNA for precise control of protein translation within cells has great promise within future orthogonal translation systems to decouple housekeeping protein metabolism from that of engineered genetic systems. Previously, E. coli strain C321.ΔA.exp lacking all UAG stop codo...
ORGANISM(S): Escherichia Coli 
2019-03-15 | PXD012390 | panorama
GenomicsAAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (mim-tRNA)
AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (mim-tRNA)
PRJNA743039 | ENA
GenomicsAAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (tRNA_charging)
AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (tRNA_charging)
PRJNA781652 | ENA
GenomicsAAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (amplicon)
AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (amplicon)
PRJNA743041 | ENA
GenomicsAAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (ribosome profiling)
AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (ribosome profiling)
PRJNA743042 | ENA
GenomicsAAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (mRNA-seq)
AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (mRNA-seq)
PRJNA781651 | ENA
OtherAAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (mim-tRNA)
In this study, we utilized a mouse model of mucopolysaccharidosis type I (MPS-I) carrying a homozygous nonsense mutation in the Idua gene (Idua-W401X, TGG→TAG) to develop rAAV-delivered sup-tRNA therapeutics that can overcome a pathogenic UAG premature termination codon (PTC).
ORGANISM(S): Mus musculus 
2021-11-30 | GSE179272 | GEO
OtherAAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (tRNA_charging)
In this study, we utilized a mouse model of mucopolysaccharidosis type I (MPS-I) carrying a homozygous nonsense mutation in the Idua gene (Idua-W401X, TGG→TAG) to develop rAAV-delivered sup-tRNA therapeutics that can overcome a pathogenic UAG premature termination codon (PTC).
ORGANISM(S): Mus musculus 
2021-11-30 | GSE189145 | GEO
OtherAAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (amplicon)
In this study, we utilized a mouse model of mucopolysaccharidosis type I (MPS-I) carrying a homozygous nonsense mutation in the Idua gene (Idua-W401X, TGG→TAG) to develop rAAV-delivered sup-tRNA therapeutics that can overcome a pathogenic UAG premature termination codon (PTC).
ORGANISM(S): Mus musculus 
2021-11-30 | GSE179270 | GEO
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