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ProteomicsUb E2 enzyme UBE2E1+ pepetide(KEGYES)_HDX-MS
The ubiquitin E2 enzyme UBE2E1 is able to catalyse ubiquitination modification of KEGYES/KEGYEE sequence-containing proteins in a manner that does not require an E3 enzyme. Here, we investigate the binding hotspot regions of UBE2E1 with the sequence KEGYES by hydrogen-deuterium exchange mass spectro...
ORGANISM(S): Homo sapiens (Human) 
2024-02-07 | PXD048115 | Pride
Ubiquitin Hdx-ms Ub e2 enzyme 
ProteomicsE2-Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells
The E2 ubiquitin (Ub)-conjugating enzyme primarily determines Ub conjugation as Ub-isopeptide (lysine), Ub-oxyester (serine/threonine) or Ub-thioester (cysteine). However, E2-specific Ub conjugation profiles within cells remain elusive. Here, we developed the fusion E2–Ub-R74G profiling (FUSEP) stra...
ORGANISM(S): Homo Sapiens 
2024-12-11 | PXD058017 |
UnknownE2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis.
Not available
S-EPMC3989626 | biostudies-literature
ProteomicsIdentification by activity-based probes of a new Plasmodium falciparum E2 ubiquitin conjugating enzyme
The ubiquitin-proteasome system (UPS) is essential for Plasmodium falciparum survival and represents a potential target for antimalarial therapies. We utilized a ubiquitin-based activity probe (Ub-Dha) to capture active ubiquitin conjugating machinery during asexual blood-stage development. Several ...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2025-03-13 | PXD056473 | Pride
Plasmodium falciparum Activity proteomics Ubiquitin 
UnknownAnatomy of the E2 ligase fold: implications for enzymology and evolution of ubiquitin/Ub-like protein conjugation.
Not available
S-EPMC2701696 | biostudies-literature
UnknownAtaxin-3 deubiquitination is coupled to Parkin ubiquitination via E2 ubiquitin-conjugating enzyme.
Not available
S-EPMC3249107 | biostudies-literature
ProteomicsNAE1/UBA3-UBE2M are E1 and E2 Enzymes for the URM1 Modification in Human Cells
The Urm1 protein, a member of the ubiquitin (Ub)-related modifier family, is highly conserved across evolution and plays a crucial role as a sulfur donor in tRNA thiolation. Despite its importance, Urm1 remains relatively understudied in mammalian eukaryotes, leading to numerous unknown functions...
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD067405 | Pride
E1/e2 enzymes lc-ms/ms 
UnknownDistinct activation of an E2 ubiquitin-conjugating enzyme by its cognate E3 ligases.
Not available
S-EPMC4343096 | biostudies-literature
UnknownSite-Specific Protein Ubiquitylation Using an Engineered, Chimeric E1 Activating Enzyme and E2 SUMO Conjugating Enzyme Ubc9.
Not available
S-EPMC8883482 | biostudies-literature
UnknownStructure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer.
Not available
S-EPMC3625138 | biostudies-literature
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