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Mutations in Ubiquilins, UBQLN2, and UBQLN4 cause familial ALS. The role of UBQLNs in proteasomal degradation is well established but their role in autophagy-lysosomal clearance is poorly defined. Here, we performed Ubqn-GFP pull down from fly samples to find Ubqn binding partners.
ORGANISM(S): Drosophila <fruit Fly, Genus> (ncbitaxon:7215) 
2018-12-18 | MSV000083259 | MassIVE
Ubiquilins are a family of proteins involved in proteasomal degradation of mislocalized membrane proteins. Here, Greer et al. demonstrate that Ubqln1 is required for BCR-driven B cell proliferation through maintenance of protein synthesis following stimulation. In the absence of Ubqln1, mitochondria...
ORGANISM(S): Mus musculus 
2017-11-01 | GSE86113 | GEO
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