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ProteomicsProteomic characterization of ubiquitin carboxyl-terminal hydrolase 19 deficient cells reveals a role for USP19 in secretion of lysosomal proteins
Ubiquitin carboxyl-terminal hydrolase 19 (USP19) is a unique deubiquitinase (DUB), characterized by multiple variants generated by alternative splicing. Several variants bear a C-terminal transmembrane domain that anchors them to the endoplasmic reticulum (ER). Other than regulating protein stabilit...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055081 | Pride
Lysosome Cathepsins. Ubiquitin carboxyl-terminal hydrolase 19  proteomics  unconventional secretion  secretome  legumain 
ProteomicsProteomic characterization of ubiquitin carboxyl-terminal hydrolase 19 deficient cells reveals a role for USP19 in secretion of lysosomal proteins
Ubiquitin carboxyl-terminal hydrolase 19 (USP19) is a unique deubiquitinase (DUB), characterized by multiple variants generated by alternative splicing. Several variants bear a C-terminal transmembrane domain that anchors them to the endoplasmic reticulum (ER). Other than regulating protein stabilit...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055064 | Pride
Lysosome Cathepsins. Ubiquitin carboxyl-terminal hydrolase 19  proteomics  unconventional secretion  secretome  legumain 
ProteomicsProteomic characterization of ubiquitin carboxyl-terminal hydrolase 19 deficient cells reveals a role for USP19 in secretion of lysosomal proteins
Ubiquitin carboxyl-terminal hydrolase 19 (USP19) is a unique deubiquitinase (DUB), characterized by multiple variants generated by alternative splicing. Several variants bear a C-terminal transmembrane domain that anchors them to the endoplasmic reticulum (ER). Other than regulating protein stabilit...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055118 | Pride
Lysosome Cathepsins. Ubiquitin carboxyl-terminal hydrolase 19  proteomics  unconventional secretion  secretome  legumain 
ProteomicsElevated cerebrospinal fluid ubiquitin carboxyl-terminal hydrolase isozyme L1 in asymptomatic C9orf72 hexanucleotide repeat expansion carriers
Importance: An intronic hexanucleotide repeat expansion (HRE) in C9orf72 is the commonest monogenic cause of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Predicting those who will develop neurodegeneration and its timing will be essential to i...
ORGANISM(S): Homo sapiens (Human) 
2024-11-19 | PXD051859 | Pride
Csf  amyotrophic lateral sclerosis  frontotemporal dementia  biomarker  mass spectrometry  proteomics  c9orf72  uchl1. 
UnknownProteomic Characterization of Ubiquitin Carboxyl-Terminal Hydrolase 19 Deficient Cells Reveals a Role for USP19 in the Secretion of Lysosomal Proteins.
Not available
S-EPMC11617723 | biostudies-literature
UnknownElevated Cerebrospinal Fluid Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 in Asymptomatic C9orf72 Hexanucleotide Repeat Expansion Carriers.
Not available
S-EPMC11831881 | biostudies-literature
UnknownUbiquitin carboxyl-terminal hydrolase isozyme L5 inhibits human glioma cell migration and invasion via downregulating SNRPF.
Not available
S-EPMC5768352 | biostudies-literature
UnknownNo evidence for neuronal damage or astrocytic activation in cerebrospinal fluid of Neuro-COVID-19 patients with long-term persistent headache.
Not available
S-EPMC10536703 | biostudies-literature
TranscriptomicsBulk RNA-Seq analysis of MC38 colon carcinoma cells and MC38 Bap1-knockout cells in vitro
In order to find out which genes Bap1 regulates to affect the anti-tumor immune response in MC38 colon carcinoma cell linewe knocked out the Bap1 gene in the MC38 cell line through CRISPR-Cas9 technology, RNA was directly isolated for RNA seq and were able to investigate gene expression.
ORGANISM(S): Mus musculus 
2025-07-06 | E-MTAB-10588 | biostudies-arrayexpress
UnknownIdentification of novel human USP2 inhibitor and its putative role in treatment of COVID-19 by inhibiting SARS-CoV-2 papain-like (PLpro) protease.
Not available
S-EPMC7487165 | biostudies-literature
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