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ProteomicsFunctional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes
Supporting .raw data for "Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes", DOI: 10.15252/embj.2021108823 Related to Figure 1E and EV1A.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-17 | MSV000088403 | MassIVE
ProteomicsInteractome of E1 ubiquitin-activating enzymes and of E2 ubiquitin-conjugating enzymes in human HEK293 cells.
Investigation of E1 ubiquitin-activating enzymes and E2 ubiquitin-conjugating enzymes interactome in human HEK293 cells.
ORGANISM(S): Homo sapiens (Human) 
2023-11-14 | PXD042361 | Pride
E1 ubiquitin-activating enzymes  e2 ubiquitin-conjugating enzymes  ubiquitin  human cells  interactome. 
GenomicsCDK4/6 inhibitors modulate the ubiquitin proteosomal pathway by suppression of the ubiquitin conjugating enzymes UBE2C/S/T
CDK4/6 inhibitors modulate the ubiquitin proteosomal pathway by suppression of the ubiquitin conjugating enzymes UBE2C/S/T
PRJNA828445 | ENA
UnknownUbiquitin-Conjugating Enzymes in Cancer.
Not available
S-EPMC8227520 | biostudies-literature
TranscriptomicsExpression data from 17 day old testes of wild type and UBR2-/- mice
Ubiquitylation of histones provides an important mechanism regulating chromatin remodeling and gene expression. Recent studies have revealed ubiquitin ligases involved in histone ubiquitylation, yet the responsible enzymes and the function of histone ubiquitination in spermatogenesis remain unclear....
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-18824 | biostudies-arrayexpress
ProteomicsAuranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterificlation to E2 ubiquitin-conjugating enzymes
UBA1 is the primary E1 ubiquitin-activating enzyme, regulating stability and function of numerous proteins via initiating their ubiquitination. Decreased or insufficient ubiquitination can cause or drive aging and many deadly diseases. Therefore, a small-molecule UBA1 activity enhancer could have br...
ORGANISM(S): Homo sapiens (Human) 
2023-07-10 | PXD042558 | Pride
Ubiquitination Uba1 Auranofin 
ProteomicsTargeted protein degradation using E2 ubiquitin-conjugating enzymes
Proteins can be targeted for degradation by using engineered molecular conjugates to enhance their interaction with eukaryotic ubiquitination machinery. For instance, the fusion of an E3 ubiquitin ligase to a suitable target binding domain creates a biological ‘Proteolysis-Targeting Chimera’ (bioPRO...
ORGANISM(S): Homo sapiens (Human) 
2024-09-23 | PXD041225 | Pride
Bioprotac 
TranscriptomicsRNAseq of Arabidopsis plants lacking E2 ubiquitin conjugating enzymes UBC35 and UBC36
This RNAseq experiment aims at determining the reprogramming of gene expression upon loss of K63 polyubiquitin chain formation. Twelve-day-old plants expressing a beta-estradiol inducible artificial microRNA targeting the two plant E2 enzymes catalyzing K63 polyubiquitin chain formation were mock-tr...
ORGANISM(S): Arabidopsis thaliana 
2020-01-01 | E-MTAB-8437 | biostudies-arrayexpress
ProteomicsIdentification by activity-based probes of a new Plasmodium falciparum E2 ubiquitin conjugating enzyme
The ubiquitin-proteasome system (UPS) is essential for Plasmodium falciparum survival and represents a potential target for antimalarial therapies. We utilized a ubiquitin-based activity probe (Ub-Dha) to capture active ubiquitin conjugating machinery during asexual blood-stage development. Several ...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2025-03-13 | PXD056473 | Pride
Plasmodium falciparum Activity proteomics Ubiquitin 
TranscriptomicsE2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Ubiquitin and ubiquitin-like proteins (UBLs) are directed to targets by cascades of E1, E2, and E3 enzymes. The largest ubiquitin E3 subclass consists of cullin-RING ligases (CRLs), which contain one each of several cullins (CUL1, -2, -3, -4, or -5) and RING proteins (RBX1 or -2). CRLs are activated...
ORGANISM(S): Mus musculus 
2009-03-23 | E-GEOD-14088 | biostudies-arrayexpress
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