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ProteomicsRepurposing E3 ubiquitin ligases as cell surface protein degraders using Proteolysis Targeting Antibodies
The majority of current therapeutics targeting plasma membrane receptors function by antagonizing ligand binding or enzymatic activities. Typical mammalian proteins, however, consist of multiple domains executing discrete but coordinated activities, and saturating inhibition of one functional domain...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-25 | MSV000089542 | MassIVE
GenomicsTranscriptional Regulation by Cullin Ubiquitin Ligases
Transcriptional Regulation by Cullin Ubiquitin Ligases
PRJNA614537 | ENA
GenomicsTo identify potential ubiquitin ligases that regulate BIK1 homeostasis
To identify potential ubiquitin ligases that regulate BIK1 homeostasis
PRJNA945931 | ENA
ProteomicsUbiquitin Proteomics Analysis of Systemic Sclerosis Lung Fibroblasts with or without KLHL42 knockdown
Systemic scleroderma (SSc) is an autoimmune disease which results in fibrotic production in the lung. Resultant SSC-pulmonary fibrosis is the main cause of mortality among SSc patients. From high throughput RNAi screening, we uncovered the ubiquitin E3 ligase KLHL42 as a potential pro-fibrotic media...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-14 | MSV000084800 | MassIVE
OtherA systems-wide screen identifies substrates of the SCF-beta-TrCP ubiquitin ligase.
Data from ProteomeXchange, PXD ID: PXD001224. File: OR3_100623_BTrCP_EV_IP_Band01.mzml. Published as part of Sci Signal. 2014 Dec 16;7(356):rs8 . From the Abstract: {{i}} ... We developed a combined bioinformatics and affinity purification-mass spectrometry (AP-MS) workflow for the system-wide iden...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320006530 | GPMDB
Resource Reanalysis 
GenomicsCombinatorial mapping of E3 ubiquitin ligases to their target substrates
Combinatorial mapping of E3 ubiquitin ligases to their target substrates
PRJNA982147 | ENA
GenomicsStructural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases
Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases
PRJNA624321 | ENA
GenomicsSIAH ubiquitin E3 ligases as modulators of inflammatory gene expression
SIAH ubiquitin E3 ligases as modulators of inflammatory gene expression
PRJNA742677 | ENA
UnknownChain reactions: molecular mechanisms of RBR ubiquitin ligases.
Not available
S-EPMC7458406 | biostudies-literature
TranscriptomicsPost-transcriptional fine-tuning of COP9 signalosome subunit biosynthesis is regulated by the c-Myc/Lin28B/let-7 pathway
The COP9 signalosome (CSN) is a conserved protein complex occurring in all eukaryotes. The mammalian CSN consists of eight subunits (CSN1 – CSN8) and possesses an intrinsic metalloprotease JAMM motif localised to CSN5. In addition, it is associated with kinases such as protein kinase CK2 and D and t...
ORGANISM(S): Homo sapiens 
2011-10-26 | E-GEOD-19085 | biostudies-arrayexpress
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