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ModelsProctor2007 - Age related decline of proteolysis, ubiquitin-proteome system
Proctor2007 - Age related decline of proteolysis, ubiquitin-proteome system This is a stochastic model of the ubiquitin-proteasome system for a generic pool of native proteins (NatP), which have a half-life of about 10 hours under normal conditions. It is assumed that these ...
2024-09-02 | BIOMD0000000105 | BioModels
ProteomicsNEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress
SILAC quantitative mass spectrometry analysis on protein aggregates induced upon heat shock. Two separate performed analysis: A) control siRNA cells (light) with siRNA NEDD8 cells (heavy) and B) control cells (light) with MLN4924 treated cells (heavy). In all conditions cells were heat shocked at 43...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-17 | MSV000082623 | MassIVE
ProteomicsDiacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans
Proteomic data from human airway epithelial cells treated with PBS and diacetyl vapor for two consecutive days. Samples were digested with trypsin, then analyzed by LC-MS/MS. Data was searched with MaxQuant.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-15 | MSV000086874 | MassIVE
ProteomicsIdentification of novel ubiquitin receptors on the 26S proteasome by photo-crosslinking mass spectrometry
The 26S proteasome is the endpoint of the ubiquitin-proteasome system, an essential pathway for maintaining cellular homeostasis through targeted degradation of misfolded, damaged, and obsolete proteins. Substrates labeled with ubiquitin are directed to the 26S proteasome by binding to one or more u...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-06-08 | PXD075114 | Pride
26s proteasome Ubiquitin Ubiquitin receptors 
GenomicsUbiquitin-Proteasome System Dysregulation in Alzheimer's Disease Impacts Protein Abundance
Ubiquitin-Proteasome System Dysregulation in Alzheimer's Disease Impacts Protein Abundance
PRJNA1449257 | ENA
TranscriptomicsRNAi knock down of VCP in human HeLa cells
Study of the effects of the VCP knockdown. VCP (p97, yeast cdc48) is a hexameric AAA ATPase involved in various cellular functions including degradation of proteins by the ubiquitin-proteasome system. We examine the consequences of the reduction of VCP levels after RNAi of VCP in HeLa cells. We find...
ORGANISM(S): Homo sapiens 
2006-08-23 | E-MEXP-817 | biostudies-arrayexpress
UnknownActivation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy.
Not available
S-EPMC8791501 | biostudies-literature
ModelsSneppen2009 - Modeling proteasome dynamics in Parkinson's disease
Sneppen2009 - Modeling proteasome dynamics in Parkinson's disease This model is described in the article: Modeling proteasome dynamics in Parkinson's disease. Sneppen K, Lizana L, Jensen MH, Pigolotti S, Otzen D. Phys Biol 2009; 6(3): 036005 Abstract: In Parkinson's d...
2024-09-02 | BIOMD0000000548 | BioModels
TranscriptomicsTranscription profiling of rat liver and adipose tissues after 24 h-fasting
The functional balance between brown adipose tissue (BAT) and white adipose tissue (WAT) is important for metabolic homeostasis. We compared the effects of fasting on the gene expression profiles in BAT, WAT and liver, using DNA microarray analysis. Tissues were obtained from rats that had been fe...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7623 | biostudies-arrayexpress
TranscriptomicsThe FoxO signature in protein breakdown
Under stress conditions mammalian cells activate compensatory mechanisms to survive and maintain cellular function. During catabolic conditions, such as low nutrients, systemic inflammation, cancer or infections, protein breakdown is enhanced and aminoacids are released from muscles to sustain liver...
ORGANISM(S): Mus musculus 
2015-04-24 | E-GEOD-52667 | biostudies-arrayexpress
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