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MetabolomicsUrinary Ubiquitin-Specific Protease 2 (USP2) as a Diagnostic Biomarker for Chronic Kidney Disease: An Integrated Multi-Omics and Network Analysis
Urinary USP2 is elevated in chronic kidney disease and shows strong diagnostic performance. Integrated metabolomics and proteomics analyses identified cortisol and prostaglandin A3 as candidate mediators and linked USP2 to lipid metabolism and ferroptosis-related pathways.
2026-05-05 | MTBLS14426 | MetaboLights
MetabolomicsProteomics and tracer metabolomics link GAPDH ISGylation to glycolytic control

Ubiquitin-like protein ISG15 (interferon-stimulated gene 15) has been implicated in the regulation of central carbon metabolism, but conflicting findings across experimental systems have limited mechanistic insight. Here, we applied a multi-omics approach in cells ectopically expressing the ISGyl...

2026-03-02 | MTBLS12619 | MetaboLights
ProteomicsCRL4(CRBN) ubiquitin ligase profiling
In the 1950s the drug thalidomide administered as a sedative to pregnant women led ot the birth of thousands of children with multiple defects. Despite its teratogenicity, thalidomide and ist IMiD derivatives recently emerged as effective treatments for multiple myeloma and 5q-dysplasia. IMiDs targe...
ORGANISM(S): Homo sapiens 
2014-05-13 | E-GEOD-57554 | biostudies-arrayexpress
ProteomicsUbiquitin S65 proteomics: Targets of ubiquitin phosphorylation
Ubiquitylation is an essential post-translational modification that regulates numerous cellular processes, most notably protein degradation. Ubiquitin itself can be post-translationally modified by phosphorylation, with nearly every serine, threonine, and tyrosine residue having the potential to be...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-07-07 | PXD002201 | Pride
Yeast Orbitrap Phosphorylation Ubiquitin 
ProteomicsUbiquitin S65 proteomics: H2O2 ubiquitylation response
Ubiquitylation is an essential post-translational modification that regulates numerous cellular processes, most notably protein degradation. Ubiquitin itself can be post-translationally modified by phosphorylation, with nearly every serine, threonine, and tyrosine residue having the potential to be...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-07-07 | PXD002200 | Pride
Yeast Orbitrap Phosphorylation Ubiquitin 
ProteomicsUbiquitin S65 proteomics: H2O2 phosphorylation response
Ubiquitylation is an essential post-translational modification that regulates numerous cellular processes, most notably protein degradation. Ubiquitin itself can be post-translationally modified by phosphorylation, with nearly every serine, threonine, and tyrosine residue having the potential to be...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-07-07 | PXD002198 | Pride
Yeast Orbitrap Phosphorylation Ubiquitin 
ProteomicsUbiquitin Proteomics Analysis of Systemic Sclerosis Lung Fibroblasts with or without KLHL42 knockdown
Systemic scleroderma (SSc) is an autoimmune disease which results in fibrotic production in the lung. Resultant SSC-pulmonary fibrosis is the main cause of mortality among SSc patients. From high throughput RNAi screening, we uncovered the ubiquitin E3 ligase KLHL42 as a potential pro-fibrotic media...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-14 | MSV000084800 | MassIVE
ProteomicsUbiquitin S65 proteomics: H2O2 whole cell lysate protein response
Ubiquitylation is an essential post-translational modification that regulates numerous cellular processes, most notably protein degradation. Ubiquitin itself can be post-translationally modified by phosphorylation, with nearly every serine, threonine, and tyrosine residue having the potential to be...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-07-07 | PXD002197 | Pride
Yeast Orbitrap Phosphorylation Ubiquitin 
ProteomicsMaxQuant.Live enables enhanced selectivity and identification of peptides modified by endogenous SUMO and ubiquitin
Small ubiquitin-like modifiers (SUMOs) and ubiquitin are frequent post-translational modifications of proteins that play pivotal roles in all cellular processes. We previously reported mass spectrometry-based proteomics methods that enable profiling of lysines modified by endogenous SUMO or ubiquiti...
ORGANISM(S): Homo sapiens (Human) 
2021-02-05 | PXD022367 | Pride
Peptide mass filtering Sumo Mql Ubiquitin Maxquant.live Precursor untargeting 
ProteomicsUbiquitin S65 proteomics: H2O2 Histag affinity purification protein response
Ubiquitylation is an essential post-translational modification that regulates numerous cellular processes, most notably protein degradation. Ubiquitin itself can be post-translationally modified by phosphorylation, with nearly every serine, threonine, and tyrosine residue having the potential to be...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-07-07 | PXD002199 | Pride
Yeast Orbitrap Phosphorylation Ubiquitin 
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