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ProteomicsStructural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
Inhibition of the mitochondrial deubiquitinating enzyme USP30 is neuroprotective and presents therapeutic opportunities for the treatment of idiopathic Parkinson’s Disease and mitophagy-related disorders. We have integrated structural and quantitative proteomics with biochemical assays to decipher t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054057 | Pride
Ubiquitin specific protease usp30  cyanopyrrolidine inhibitors Activity-based protein profiling mass spectrometry  enzyme kinetics  hydrogen deuterium exchange-mass spectrometry  molecular docking Mitophagy 
ProteomicsStructural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
Inhibition of the mitochondrial deubiquitinating enzyme USP30 is neuroprotective and presents therapeutic opportunities for the treatment of idiopathic Parkinson’s Disease and mitophagy-related disorders. We have integrated structural and quantitative proteomics with biochemical assays to decipher t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054041 | Pride
Ubiquitin specific protease usp30  cyanopyrrolidine inhibitors Activity-based protein profiling mass spectrometry  enzyme kinetics  hydrogen deuterium exchange-mass spectrometry  molecular docking Mitophagy 
ProteomicsDiscovery of highly Potent and Selective Activity-Based Probes for the Deubiquitylating Enzyme USP30
Ubiquitin-specific protease 30 (USP30) is a deubiquitylating enzyme (DUB) localized in the mitochondrial membrane, which is related to PINK1/Parkin-mediated mitophagy, pexophagy, BAX/BAK-dependent apoptosis, and IKKβ-USP30-ACLY-regulated lipogenesis/tumorigenesis. Mission therapeutics pointed their ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD044792 | Pride
Usp30  activity-based probes  chemical probes  desi  deubiquitinase. 
UnknownStructural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor.
Not available
S-EPMC11812085 | biostudies-literature
UnknownChimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30.
Not available
S-EPMC12440824 | biostudies-literature
ProteomicsStructural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
Dampening functional levels of the mitochondrial deubiquitylating enzyme USP30 has been suggested as an effective therapeutic strategy against neurodegenerative disorders such as Parkinson’s Disease. USP30 inhibition may counteract the deleterious effects of impaired turnover of damaged mitochondria...
ORGANISM(S): Homo Sapiens 
2026-01-12 | PXD042782 | panorama
UnknownMechanism and regulation of the Lys6-selective deubiquitinase USP30.
Not available
S-EPMC5757785 | biostudies-literature
UnknownIdentification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30.
Not available
S-EPMC9397470 | biostudies-literature
UnknownStructural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides.
Not available
S-EPMC10400906 | biostudies-literature
UnknownDiscovery of potent and selective activity-based probes (ABPs) for the deubiquitinating enzyme USP30.
Not available
S-EPMC11078216 | biostudies-literature
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