Ubiquitin-mediated degradation

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Homo sapiens (226)
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Organisms

Homo sapiens (114)
Mus musculus (78)
Saccharomyces cerevisiae (11)
Arabidopsis thaliana (10)
Rattus norvegicus (5)
Drosophila melanogaster (3)
Solanum lycopersicum (2)
Cryptococcus neoformans H99 (1)
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Cryptococcus neoformans (1)
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Oncorhynchus mykiss (1)
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502779 (1)
Sus scrofa (1)
Gallus gallus (1)
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Primary cell (2)
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Technology Type

Mass Spectrometry (188)
Shotgun proteomics (94)
Affinity purification coupled with mass spectrometry proteomics (33)
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Gel-based experiment (22)
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Data-independent acquisition (15)
SWATH MS (6)
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Mass spectrometry assay (4)
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SRM/MRM (2)
All-ion fragmentation (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)

Instrument Platform

Illumina NovaSeq 6000 (10)
Q Exactive (7)
TSQ Quantiva (5)
Illumina HiSeq 2000 (4)
Orbitrap Exploris 480 (4)
Orbitrap Fusion Lumos (4)
Q Exactive Plus (4)
Illumina HiSeq 2500 (3)
Orbitrap Eclipse (3)
Orbitrap Fusion (3)
LTQ Orbitrap (2)
LTQ Orbitrap Velos (2)
TimsTOF Pro (2)
Agilent TapeStation (1)
Element AVITI (1)
GenePix 4000A [Axon Instruments] (1)
G2565AA DNA microarray scanner [Agilent] (1)
GenePix 4000B [Axon Instruments] (1)
Ion Torrent PGM (1)
None (1)
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Instrument (1)
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TimsTOF (1)
TimsTOF HT (1)

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2013 (25)
2012 (23)
2010 (22)
2008 (22)
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2011 (20)
2019 (19)
2015 (19)
2018 (18)
2016 (11)
2007 (6)
2009 (5)
2006 (2)
2004 (1)
2005 (1)

UNIPROT ID/AC

P00441 (1)
P20711 (1)
P78417 (1)
P07203 (1)
P30838 (1)
P21397 (1)
Q05940 (1)
P11142 (1)
P61088 (1)
Q13404 (1)
Q9Y6H5 (1)
O14933 (1)
P0CG47 (1)
P07101 (1)
P22314 (1)
P04040 (1)
O60260 (1)
P09936 (1)
P37840 (1)

CHEBI ID

CHEBI:17895 (2)
CHEBI:15356 (1)
CHEBI:24432 (1)
CHEBI:32952 (1)
CHEBI:50910 (1)
CHEBI:60027 (1)
CHEBI:27404 (1)
CHEBI:36141 (1)
CHEBI:29191 (1)
CHEBI:16234 (1)
CHEBI:18243 (1)
CHEBI:29034 (1)
CHEBI:27978 (1)
CHEBI:17858 (1)
CHEBI:41941 (1)
CHEBI:29033 (1)
CHEBI:16856 (1)
CHEBI:16670 (1)
CHEBI:18421 (1)
CHEBI:16240 (1)
CHEBI:15377 (1)
CHEBI:15765 (1)
CHEBI:15379 (1)
CHEBI:15846 (1)
CHEBI:16908 (1)
CHEBI:16526 (1)
CHEBI:16134 (1)
CHEBI:15422 (1)
CHEBI:31006 (1)
CHEBI:141071 (1)

Metabolite Name

Adenosine (4)
Anserine (3)
L-Lysine (3)
Betaine (3)
L-Alanine (3)
Choline (3)
Glycylproline (3)
L-Glutamine (3)
L-Tryptophan (3)
L-Valine (3)
L-Leucine (3)
L-Tyrosine (3)
L-Phenylalanine (3)
Octaethyleneglycol monododecyl ether (2)
Epsilon-Maleimido-lysine (2)
Aminopentol (2)
Tryptophanamide (2)
Aminoadipic acid (2)
S-Hydroxymethylglutathione (2)
N-Acetylasparagine (2)
Diisobutyl phthalate (2)
P-Octopamine (2)
Fructose 6-phosphate (2)
4-Hydroxyproline (2)
Bicine (2)
Allantoic acid (2)
2-Hydroxy-2-methylbutyric acid (2)
N6,N6,N6-Trimethyl-L-lysine (2)
Citicoline (2)
L-Pipecolic acid (2)

First Public Date

2026 (50)
2024 (48)
2025 (47)
2023 (22)
2020 (22)
2021 (16)
2022 (15)
2014 (15)
2017 (13)
2019 (12)
2018 (8)
2015 (6)
2016 (2)
2013 (1)

Modelling Approach

Ordinary differential equation model (2)
Boolean model (1)

Lab affiliation

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (21)
Immunology Research Center, National Health Research Institutes, Zhunan, Taiwan Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas (4)
Department of Biology, University of Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany (3)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA (3)
Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou City, China. (3)
Fondazione Ri.MED (3)
1Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China (2)
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, 75390, TX, USA (2)
Department of Clinical Laboratory, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing, China. (2)
Department of Pathology and Cell Biology and Institute for Cancer Genetics Herbert Irving Comprehensive Cancer Vagelos College of Physicians & Surgeons Columbia University (2)
Functional Proteomics, ICR (2)
IBC R602,128, Academia Road Sec. 2, Nankang, Taipei 115, Taiwan (2)
Institut Pasteur Unité des Interactions Bactéries-Cellules, Inserm U604, INRA USC2020 25 rue du Dr. Roux 75015 Paris France (2)
State Key Laboratory of Oncology in South China (2)
The University of Melbourne (2)
University of Freiburg, Institute of Biology II, Biochemistry/Functional Proteomics (2)
1 Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry,Germany. 2 NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (1)
1Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea (1)
2 College of Horticulture, South China Agricultural University, Guangzhou 510642, China (1)
Assistant Professor, Department of Cell Biology Van Andel Institute (1)
Assistant Professor, School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, HK SAR (1)
Associate Professor of Biochemistry & Molecular Biology, Director Proteomics Core, Indiana University School of Medicine (1)
Associate Professor, Head Cancer Proteomics Group, University of Queensland Diamantina Institute, Woolloongabba, QLD, 4102 (1)
Associate Professor, Mayor Lab, Department of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, 2125 East Mall, Vancouver, BC V6T1Z4, Canada (1)
Australian Regenerative Medicine Institute, Monash University, Wellington Road, Clayton, VIC 3800, Australia (1)
BPMP, CNRS, INRAE, Institut Agro, Univ Montpellier, 34060 Montpellier, France (1)
Basic Research Lab for “Epigenetic Regeneration of Aged Skeleto-Muscular System (ERASMUS)”, Department of Molecular Genetics and Dental Pharmacology, School of Dentistry, Dental Research Institute, Seoul National University, Seoul, South Korea (1)
Biochemistry & Functional Proteomics, Institute of Biology II, University of Freiburg, Freiburg, Germany (1)
Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (1)
Biology Department, University of Massachusetts Boston, Boston, MA, USA (1)

IsPrivate

False (3)

Classification

fungi (3)

Modification

Heavy form - site K (1)
Light form - site K (1)

Study type

Transcription profiling by array (122)
RNA-seq of coding RNA (25)
ChIP-seq (6)
ChIP-chip by tiling array (4)
Unknown experiment type (3)
Comparative genomic hybridization by array (3)
RNA-seq of total RNA (3)
RNAi profiling by array (2)
Transcription profiling by RT-PCR (2)
RNA-seq of non coding RNA (2)
High-throughput sequencing (1)
Cell line - High-throughput sequencing (1)
Ribo-seq (1)
CUT&RUN (1)
Genotyping by high throughput sequencing (1)

Release Date

2025 (381)
2024 (299)
2023 (290)
2022 (275)
2020 (237)
2021 (234)
2019 (200)
2016 (173)
2018 (168)
2017 (161)
2014 (152)
2015 (139)
2013 (117)
2012 (114)
2011 (101)
2010 (99)
2009 (79)
2026 (74)
2008 (68)
2007 (36)
2006 (31)
2004 (16)
2005 (16)
2003 (9)
2002 (6)
2001 (6)
1999 (4)
2000 (2)
1998 (1)

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Unveiling superior phenol detoxification and degradation ability in Candida tropicalis SHC-03: A comparative study with Saccharomyces cerevisiae BY4742

This study examined the phenol degradation capabilities and oxidative stress responses of Candida tropicalis SHC-03, demonstrating its metabolic superiority and resilience compared to Saccharomyces cerevisiae BY4742 in a culture medium with phenol as the sole carbon source. Through comparative gr...

2024-10-04 | MTBLS10757 | MetaboLights

Distinct Protein Degradation Induced by Different Disuse Models of Skeletal Muscle Atrophy

Skeletal muscle atrophy is a consequence of many diseases, environmental insults, inactivity, age and injury. Atrophy is characterized by active degradation and removal of contractile proteins and a reduction in fiber size. Animal models have been extensively used to identify pathways leading to a...

ORGANISM(S): Mus musculus

2011-10-24 | E-GEOD-25908 | biostudies-arrayexpress

Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

The activity of Src-family kinases (SFKs), which phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs), is a critical factor regulating myeloid-cell activation. In a previous paper (Freedman et al., 2015) we showed that the SFK LynA is uniquely susceptible to rapid ubiquitin-mediated...

ORGANISM(S): Mus Musculus

2019-07-15 | PXD014621 | panorama

KCMF1 links RAD6 to UBR4 and lysosome-mediated degradation

Raw mass spec. data files, converted peak lists and TPP results files for KCMF1 links RAD6 to UBR4 and lysosome-mediated degradation by Hong et. al, MCP 2014. RAD6 is a ubiquitin E2 protein with roles in a number of different biological processes. Here, using affinity purification coupled with mass ...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2015-01-01 | MSV000078983 | MassIVE

ASB9 promotes ubiquitin-mediated degradation of TNP2 to facilitate histone-to-protamine transition in humans and mice

During spermiogenesis, nuclear remodeling occurs where histones are initially replaced by transition proteins (TNPs) and subsequently by protamines, a process essential for sperm maturation. Although the degradation of histones and TNPs is thought to be essential for sperm nuclear remodeling, the un...

ORGANISM(S): Mus Musculus

2025-11-19 | PXD070974 |

Role of Ubiquitin-Mediated Degradation System in Plant Biology.

Not available

S-EPMC4897311 | biostudies-literature

Ubiquitin ligase COP1 suppresses microglia-mediated inflammation

PRJNA607249 | ENA

Ubiquitin-mediated proteasome degradation regulates optic fissure fusion.

Not available

S-EPMC6602337 | biostudies-literature

Nitric Oxide Signaling and Its Association with Ubiquitin-Mediated Proteasomal Degradation in Plants.

Not available