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GenomicsProteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function
Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function
PRJNA419745 | ENA
ProteomicsCullin-RING ligases target substrates with geometrically optimized catalytic partners
Cullin-RING ubiquitin ligases (CRLs) control the degradation of a wide landscape of human proteins in combination with ubiquitin-carrying enzymes (UCEs). CRL expansion during evolution is apparent, with a few dozen in yeast that function with a single UCE and as many as 300 in humans that function w...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD043523 | Pride
Ubiquitylation Cullin-ring ligase 
UnknownNon-lysine ubiquitylation: Doing things differently.
Not available
S-EPMC9527308 | biostudies-literature
ProteomicsGlobal ubiquitylation analysis of mitochondria in primary neurons following PINK1-dependent activation of Parkin
Dataset analyzed in "Global ubiquitylation analysis of mitochondria in primary neurons following PINK1-dependent activation of Parkin" paper. Experiment TMT-labeled neurons untreated vs 5h AO treatment: 1) Membrane Proteome: .raw files AO2445-AO2456 2) Ubiquitylome: .raw files AO2433-AO2438 Experi...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-06-16 | MSV000087639 | MassIVE
TranscriptomicsProteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function
VCP is an evolutionary conserved ubiquitin-dependent ATPase that mediates the degradation of proteins through the ubiquitin-proteasome pathway. Despite the central role of VCP in the regulation of protein homeostasis, identity and nature of its cellular substrates remain poorly defined. Here, we com...
ORGANISM(S): Homo sapiens 
2018-02-08 | GSE107313 | GEO
ProteomicsProteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function
VCP is an evolutionary conserved ubiquitin-dependent ATPase that mediates the degradation of proteins through the ubiquitin-proteasome pathway. Despite the central role of VCP in the regulation of protein homeostasis, identity and nature of its cellular substrates remain poorly defined. Here, we com...
ORGANISM(S): Homo sapiens (Human) 
2018-02-09 | PXD003936 | Pride
Ubiquitin-proteasome system Ubiquitin remnant profiling Quantitative mass spectrometry Protein homeostasis Vcp 
UnknownProteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.
Not available
S-EPMC5891417 | biostudies-literature
ProteomicsUbiquitylation by the GID/CTLH complex regulates the metabolic and innate immune response of macrophages to infection by Mycobacterium tuberculosis
The GID/CTLH E3 ligase complex is implicated in several biological processes, yet its full substrate repertoire remains poorly defined. We recently identified the complex as a broad modulator of macrophage responses to Mycobacterium tuberculosis (Mtb) infection. Here, we use label-free proteomics a...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-24 | PXD075792 | Pride
Metabolism Innate immunity Ubiquitylation Tuberculosis Gid/ctlh complex Macrophages 
UnknownDisorders of ubiquitylation: unchained inflammation.
Not available
S-EPMC9075716 | biostudies-literature
UnknownRemodeling Membrane Binding by Mono-Ubiquitylation.
Not available
S-EPMC6723200 | biostudies-literature
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