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GenomicsUCHL5 promotes Tumorigenesis of Bladder Cancer by Activating AKT/mTOR signaling pathway and targeting c-myc, SLC25A19, and ICAM5.
UCHL5 promotes Tumorigenesis of Bladder Cancer by Activating AKT/mTOR signaling pathway and targeting c-myc, SLC25A19, and ICAM5.
PRJNA872911 | ENA
TranscriptomicsUCHL5 promotes Tumorigenesis of Bladder Cancer by Activating AKT/mTOR signaling pathway and targeting c-myc, SLC25A19, and ICAM5.
Purpose: To investigate the tumor-promoting role of UCHL5 in bladder cancer. Method: We established the UCHL5 knockdown cell line in which the target gene was knocked down by shRNA. RNA was extracted from cells using trizol reagent(Invitrogen) Result: Through RNA-sequencing analysis of wild-type and...
ORGANISM(S): Homo sapiens 
2025-08-02 | GSE211924 | GEO
UnknownUCHL5 controls β-catenin destruction complex function through Axin1 regulation.
Not available
S-EPMC8901634 | biostudies-literature
UnknownSynthesis and evaluation of tiaprofenic acid-derived UCHL5 deubiquitinase inhibitors.
Not available
S-EPMC7880549 | biostudies-literature
GenomicsIn vivo CRISPR screens in Head and Neck Cancer reveal that Uchl5 modulates extracellular matrix deposition to promote immune evasion.
In vivo CRISPR screens in Head and Neck Cancer reveal that Uchl5 modulates extracellular matrix deposition to promote immune evasion.
PRJNA1211115 | ENA
TranscriptomicsIn vivo CRISPR screens in Head and Neck Cancer reveal that Uchl5 modulates extracellular matrix deposition to promote immune evasion.
Recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy with a high unmet need for enhancing immunotherapy given current modest responses. Here, we performed an in vivo CRISPR screen in a HNSCC mouse model to identify immune evasion genes. We identified several...
ORGANISM(S): Mus musculus 
2025-08-14 | GSE287094 | GEO
UnknownNLRP3 Regulates Mandibular Healing through Interaction with UCHL5 in MSCs.
Not available
S-EPMC9910010 | biostudies-literature
UnknownPositive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis.
Not available
S-EPMC5825037 | biostudies-literature
TranscriptomicsIn vivo CRISPR screens in Head and Neck Cancer reveal that Uchl5 modulates extracellular matrix deposition to promote immune evasion [in vitro]
Recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy with a high unmet need for enhancing immunotherapy given current modest responses. Here, we performed an in vivo CRISPR screen in a HNSCC mouse model to identify immune evasion genes. We identified several...
ORGANISM(S): Mus musculus 
2025-06-07 | GSE269444 | GEO
TranscriptomicsIn vivo CRISPR screens in Head and Neck Cancer reveal that Uchl5 modulates extracellular matrix deposition to promote immune evasion [in vivo]
Recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy with a high unmet need for enhancing immunotherapy given current modest responses. Here, we performed an in vivo CRISPR screen in a HNSCC mouse model to identify immune evasion genes. We identified several...
ORGANISM(S): Mus musculus 
2025-06-07 | GSE269445 | GEO
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