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TranscriptomicsDevelopmental gene expression of Xenopus laevis J strain [stage]
Comprehensive RNA-seq experiments to measure the expression of homoeologs across different developmental stages, as a part of the Xenopus laevis genome project. This work is funded by Agency Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT; "Genome Science" Gra...
ORGANISM(S): Xenopus laevis 
2016-10-24 | E-GEOD-73430 | biostudies-arrayexpress
TranscriptomicsTissue gene expression of Xenopus laevis J strain [tissue]
Comprehensive RNA-seq experiments to measure the expression of homoeologs across different tissues, as a part of the Xenopus laevis genome project. This work is funded by Agency Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT; "Genome Science" Grant ID 221S000...
ORGANISM(S): Xenopus laevis 
2016-10-24 | E-GEOD-73419 | biostudies-arrayexpress
TranscriptomicsA Xenopus DNA microarray approach to identify novel direct BMP target genes involved in early embryonic development
Bone Morphogenetic Proteins (BMPs), a subgroup of the TGF- superfamily, were originally isolated from bone on the basis of their ability to induce ectopic bone development. While BMPs are involved in a wide range of developmental and physiological functions, very few vertebrate target genes in t...
ORGANISM(S): Xenopus laevis 
2010-06-10 | E-GEOD-2274 | biostudies-arrayexpress
TranscriptomicsAssociation of prognosis of acute myeloid leukemia patients with leukemia stem cell gene signature based on nucleostemin promoter activity
Acute myeloid leukemia (AML) is a heterogeneous neoplastic disorder, in which only a subset of cells have function as leukemia-initiating cells (LICs). In this study, we prospectively evaluated leukemia-initiating capacity of fractionated subpopulations of AML cells depending on expression of a nucl...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-58032 | biostudies-arrayexpress
TranscriptomicsIdentification of neural genes using Xenopus DNA microarrays
In order to isolate novel genes regulating neural induction, we utilized a DNA microarray approach. As neural induction is thought to occur via the inhibition of BMP signaling, BMP signaling was inhibited in ectodermal cells by overexpression of a dominant-negative receptor. RNAs were isolated from...
ORGANISM(S): Xenopus laevis 
2010-06-10 | E-GEOD-2266 | biostudies-arrayexpress
TranscriptomicsIdentification of genes regulated by XOct-25 overexpression in Xenopus ectoderm
The Xenopus POU class V transcription factor XOct-25 has been shown to inhibit BMP-dependent epidermal differentiation and promote neural induction in the ectoderm during early embryogenesis. In order to identify genes that act downstream of XOct-25, transcriptional profile of Xenopus ectodermal ce...
ORGANISM(S): Xenopus laevis 
2012-10-05 | E-GEOD-24562 | biostudies-arrayexpress
ProteomicsProteomic analyses of iron deprived NK92 cells with deferoxamine or PPMX-T003
This work aims to detect the differentially expressed proteins between transferrin receptor 1 inhibition and iron chelation in a natural killer cell lymphoma-derived cell line NK92. Cells were treated with 500 μM deferoxamine or 10 μg/mL PPMX-T003 (an anti-transferrin receptor 1 inhibitory antibody)...
ORGANISM(S): Homo Sapiens (human) 
PXD059223 | JPOST Repository
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
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