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ProteomicsProteomic QSAR analysis of calpain substrate specificity
Calpains are intracellular Ca2+-regulated cysteine proteases that are essential for various cellular functions. Mammalian conventional calpains (calpain-1 and calpain-2) modulate the structure and function of their substrates by limited proteolysis; however, their substrate specificity remains uncle...
ORGANISM(S): Bos taurus (Bovine) Oryctolagus cuniculus algirus Mus musculus (Mouse) Homo sapiens (Human) Gallus gallus (Chicken) Ovis aries Sus scrofa domesticus (domestic pig) Rattus norvegicus (Rat) 
2016-07-19 | PXD002532 | Pride
Calpain Pls Qsar Substrate specificity 
TranscriptomicsRing1B Promotes Hepatic Stem/Progenitor Cell Expansion via Simultaneous Suppression of Cdkn1a and Cdkn2a
The expansion of hepatic stem/progenitor cells requires Ring1B-mediated epigenetic silencing of Cdkn1a and Cdkn2a, demonstrating that Ring1B simultaneously regulates multiple CDKI in tissue stem/progenitor cells. Comparison of gene expression profiles between Ring1B KO and WT murine liver cells at E...
ORGANISM(S): Mus musculus 
2014-04-01 | E-GEOD-54116 | biostudies-arrayexpress
TranscriptomicsGene expression profile of L428 cells conditional expressing PU.1
PU.1 is an Ets family transcription factor that is essential for the differentiation of both myeloid and lymphoid cells. PU.1 is down-regulated in classical Hodgkin lymphoma cells via methylation of the PU.1 promoter. To evaluate whether down-regulation of PU.1 is essential for the growth of cHL cel...
ORGANISM(S): Homo sapiens 
2012-11-22 | E-GEOD-42437 | biostudies-arrayexpress
TranscriptomicsGene expression profile of KM-H2 cells conditional expressing PU.1
PU.1 is an Ets family transcription factor that is essential for the differentiation of both myeloid and lymphoid cells. PU.1 is down-regulated in classical Hodgkin lymphoma cells via methylation of the PU.1 promoter. To evaluate whether down-regulation of PU.1 is essential for the growth of cHL cel...
ORGANISM(S): Homo sapiens 
2012-11-22 | E-GEOD-42440 | biostudies-arrayexpress
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