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MetabolomicsUntargeted Plasma Lipidomics Identifies Oxidative Stress and Inflammation Signatures Associated with Recurrent Leg Ulcer Status in Sickle Cell Disease

Leg ulcers are among the most burdensome complications of sickle cell disease (SCD), yet the molecular determinants underlying ulcer susceptibility and recurrence remain incompletely characterized. We performed untargeted plasma lipidomics by LC–MS in 129 individuals with SCD from the REDS-III Br...

2025-12-19 | MTBLS13538 | MetaboLights
ProteomicsGastric ulcer mice gastric tissue
Indomethacin was applied to establish a mice model of gastric ulcer, 24 h later, gastric tissue were obtain
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD058482 | Pride
Mice Gastric tissue Gastric ulcer 
TranscriptomicsComparative genomic hybridization of single colony purified H. pylori adhesin phenotyped isolates obtained from 25 cases and 71 controls in a Swedish case-control study of gastric cancer
Helicobacter pylori enhances the risk for ulcer disease and gastric cancer, yet only a minority of H. pylori-colonized individuals develop disease. We examined the ability of two H. pylori isolates to induce differential host responses in vivo or in vitro, and then used an H. pylori whole genome mic...
ORGANISM(S): Helicobacter pylori 
2005-06-30 | E-SMDB-1587 | biostudies-arrayexpress
GenomicsDiabetic foot ulcer mycobiome
Phylogeny of the diabetic foot ulcer mycobiome of an Afro-Caribbean population
PRJEB81942 | ENA
TranscriptomicsH. pylori strain comparisons
Helicobacter pylori enhances the risk for ulcer disease and gastric cancer, yet only a minority of H. pylori-colonized individuals develop disease. We examined the ability of two H. pylori isolates to induce differential host responses in vivo or in vitro, and then used an H. pylori whole genome mic...
ORGANISM(S): Helicobacter pylori 
2005-08-16 | E-GEOD-3135 | biostudies-arrayexpress
GenomicsDiabetic foot ulcer microbiome
Phylogenetic profiling of the diabetic foot ulcer microbiome of an Afro-Caribbean population
PRJEB81857 | ENA
GenomicsRNA-seq differences between patients with ulcer pressures grade II vs patients with ulcer pressures grade III-IV
RNA-seq differences between patients with ulcer pressures grade II vs patients with ulcer pressures grade III-IV
PRJNA957767 | ENA
UnknownMapping the global distribution of Buruli ulcer: a systematic review with evidence consensus.
Not available
S-EPMC6614043 | biostudies-literature
TranscriptomicsTransplantation of gastric organoid-derived spasmolytic polypeptide/TFF2-expressing metaplasia (SPEM) cell lineage promotes ulcer repair in the aged stomach
Background & Aims: Spasmolytic polypeptide/TFF2-expressing metaplasia (SPEM) is known to emerge following parietal cell loss and during Helicobacter pylori infection, however its role in gastric ulcer repair is unknown. Therefore, we sought to investigate if SPEM plays a role in epithelial regenerat...
ORGANISM(S): Mus musculus 
2015-09-23 | E-GEOD-73336 | biostudies-arrayexpress
UnknownLaboratory confirmation of Buruli ulcer cases in Ghana, 2008-2016.
Not available
S-EPMC6003692 | biostudies-literature
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