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TranscriptomicsTranscription profiling of differentiated brown adipocytes from wild type, PGC-1 alpha knockout, or PGC-1 alpha knockout and PGC-1 beta knockdown mice to investigate the roles of PGC-1 coactivators in brown fat differentiation.
Mitochondria play an essential role in the ability of brown fat to generate heat, and the PGC-1 coactivators control several aspects of mitochondrial biogenesis. To investigate their specific roles in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lac...
ORGANISM(S): Mus musculus 
2007-11-27 | E-GEOD-5042 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and PGC-1 alpha knockout mouse mature brown adipocytes treated with or without dibutyryl cAMP to investigate the specific role of PGC-1 coactivators in brown fat cells
To investigate the specific role of PGC-1 coactivators in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lacking PGC-1alpha. We could then efficiently knockdown PGC-1beta expression by shRNA expression. Loss of PGC-1alpha did not alter brown fat diffe...
ORGANISM(S): Mus musculus 
2007-11-27 | E-GEOD-5041 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brown versus white tissue adipose
The aim of this study was to identify genes expressed selectively in brown adipose tissue as compared to white adipose tissue from the same animals. This analysis provides a gene set that is brown and white adipose selective. Experiment Overall Design: Interscapular brown adipose tissue and epididy...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-8044 | biostudies-arrayexpress
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