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MetabolomicsThe ULK3 kinase is a key determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising in multiple body sites,...
2022-11-14 | MTBLS5155 | MetaboLights
ProteomicsUnc-51 Like Kinase 3 (ULK3) is essential for autophagy and cell survival in multiple myeloma
Despite the availability of effective therapies such as proteasome inhibitors, multiple myeloma (MM) patients relapse with refractory disease. To identify new therapeutic targets, we assessed RNA sequencing data from CD138+ MM patient cells (n = 813) across disease stages and found that an autophagy...
ORGANISM(S): Homo sapiens (Human) 
2026-05-27 | PXD067362 | Pride
Autophagy Ulk3 Interactome Multiple myeloma 
GenomicsAnalysis of genes bound by ULK3 and of H3K27 histone modification plus/minus ULK3 silencing in SCC13 cells
Analysis of genes bound by ULK3 and of H3K27 histone modification plus/minus ULK3 silencing in SCC13 cells
PRJNA762354 | ENA
GenomicsAnalysis of genes bound by ULK3 and of H3K27 histone modification plus/minus ULK3 silencing in SCC13 cells
We report high-throughput profiling of genes bound by ULK3 and of H3K27 histone modification plus/minus ULK3 silencing in squamous cell carcinoma SCC13 cells .
ORGANISM(S): Homo sapiens 
2022-10-10 | GSE183933 | GEO
GenomicsULK3 is a key determinant of the keratinocyte self-renewal and tumorigenesis [shULK3 HKCs]
ULK3 is a key determinant of the keratinocyte self-renewal and tumorigenesis [shULK3 HKCs]
PRJNA759140 | ENA
GenomicsULK3 is a key determinant of the keratinocyte self-renewal and tumorigenesis [shULK3 SCC13]
ULK3 is a key determinant of the keratinocyte self-renewal and tumorigenesis [shULK3 SCC13]
PRJNA759139 | ENA
UnknownULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins.
Not available
S-EPMC4475061 | biostudies-literature
TranscriptomicsULK3 is a key determinant of the keratinocyte self-renewal and tumorigenesis [shULK3 HKCs]
Transcriptomic profiling of three strains of primary human keratinocytes infected with two ULK3 silencing lentivirus versus control virus
ORGANISM(S): Homo sapiens 
2022-10-10 | GSE183084 | GEO
TranscriptomicsULK3 is a key determinant of the keratinocyte self-renewal and tumorigenesis [shULK3 SCC13]
Transcriptomic profiling of human squamous cell carcinoma cells SCC13 infected with three ULK3 silencing lentivirus versus control virus
ORGANISM(S): Homo sapiens 
2022-10-10 | GSE183085 | GEO
UnknownUnc-51 Like Kinase 3 (ULK3) is essential for autophagy and cell survival in multiple myeloma.
Not available
S-EPMC12363935 | biostudies-literature
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