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MetabolomicsEpistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
About a thousand genes in the human genome encode for membrane transporters. Among these, several solute carrier proteins (SLCs), representing the largest group of transporters, are still orphan and lack functional characterization. We reasoned that assessing genetic interactions among SLCs may be a...
2021-03-29 | MTBLS2205 | MetaboLights
MetabolomicsMetabonomics uncovers a reversible proatherogenic lipid profile during infliximab therapy of inflammatory bowel disease

BACKGROUND: One-third of inflammatory bowel disease (IBD) patients show no response to infliximab (IFX) induction therapy, and approximately half of patients responding become unresponsive over time. Thus, identification of potential treatment response biomarkers are of great cl...

2022-01-13 | MTBLS239 | MetaboLights
MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
TranscriptomicsExpression data from the basolateral amygdala of Long-Evans rats with a history of limited intermittent sucrose snacks
To study the molecular mediators of naturally rewarding effects of palatable food we used a model of palatable “snacking” (Ulrich-Lai et al., 2007) in which rats are given chronic, brief access to a limited amount of sucrose solution (30%). Single housed, male Long-Evans rats (250g) (n=12 per...
ORGANISM(S): Rattus norvegicus 
2010-02-21 | E-GEOD-20344 | biostudies-arrayexpress
UnknownFrom differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells.
Not available
S-EPMC19185 | biostudies-literature
TranscriptomicsA multiplexed assay to identify condition-dependent changes in protein-protein interactions
Testing the effect of 80 small molecules on the interaction between 250 protein pairs
ORGANISM(S): Saccharomyces cerevisiae 
2012-04-02 | E-MEXP-3467 | biostudies-arrayexpress
UnknownRandomized clinical study of injectable dextrin-based hydrogel as a carrier of a synthetic bone substitute.
Not available
S-EPMC9985577 | biostudies-literature
UnknownEffect of low-flow oxygen therapy on 6 minute walk test in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: a randomized non-inferiority crossover trial.
Not available
S-EPMC13537019 | biostudies-literature
ProteomicsQuantitative Single-Cell Proteomics as a Tool to Characterize Cellular Hierarchies
Large-scale single-cell analyses are of fundamental importance in order to capture biological heterogeneity within complex cell systems, but have largely been limited to RNA-based technologies. Here we present a comprehensive benchmarked experimental and computational workflow, which establishes glo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-21 | MSV000090570 | MassIVE
TranscriptomicsTranscription profiling of mouse spinal cord from mock-infected and Theilers murine encephalomyelitis (TME)-virus infected animals - time series
Theiler’s murine encephalomyelitis (TME) is an experimentally virus-induced demyelinating leukomyelitis, displaying clinical and pathological similarities to chronic progressive multiple sclerosis.
The aim of this study was to identify pathways associated with demyelination using an assumption-f...
ORGANISM(S): Mus musculus 
2009-06-19 | E-MEXP-1717 | biostudies-arrayexpress
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