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ProteomicsStructural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization
Upon ligand binding, bone morphogenetic protein (BMP) receptors form active tetrameric complexes, comprised of two type I and two type II receptors, which then transmit signals to SMAD proteins. The link between receptor tetramerization and the mechanism of kinase activation, however, has not been e...
ORGANISM(S): Homo sapiens (Human) 
2021-08-16 | PXD022944 | Pride
Bmpr2 Alk2 Hdx-ms 
ProteomicsActivation loop phosphorylation tunes conformational dynamics underlying Pyk2 tyrosine kinase activation
Pyk2 is a multidomain non-receptor tyrosine kinase that undergoes a complex, multi-stage activation process. Ca2+-flux induces conformational rearrangements that relieve autoinhibitory FERM domain interactions. The kinase domain phosphorylates a key linker residue to recruit Src kinase. Pyk2 and Src...
ORGANISM(S): Homo sapiens (Human) 
2023-03-08 | PXD034028 | Pride
Kinase Phosphorylation Hdx-ms 
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