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TranscriptomicsTranslational profiling in the unfolded protein response
The unfolded protein response (UPR) couples cellular translation rates and gene expression to the protein folding status of the endoplasmic reticulum (ER). Upon activation, the UPR machinery elicits a general suppression of protein synthesis and activation of stress gene expression, which act coordi...
ORGANISM(S): Mus musculus 
2014-08-28 | E-GEOD-53743 | biostudies-arrayexpress
TranscriptomicsProtective unfolded protein response in human pancreatic beta cells transplanted into mice
Islet transplantation exposes beta cells to mild hyperglycemia and to the abnormal environment of the transplant site. These conditions may affect beta cells and induce the expression of genes involved in beta cell damage. Gene expression profile of human beta cells exposed to mild hyperglycemia by ...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-22097 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Pichia pastoris treated with dithiothereitol to induce unfolded protein response
Experiment aims to induce unfolded protein response in Pichia pastoris, set-up was chosen to be comparable results to DTT experiment.
ORGANISM(S): Pichia pastoris 
2008-09-23 | E-MEXP-1615 | biostudies-arrayexpress
MetabolomicsER stress inhibits liver fatty acid oxidation while unmitigated stress leads to anorexia-induced lipolysis and both liver and kidney steatosis
The unfolded protein response (UPR), induced by endoplasmic reticulum (ER) stress, regulates the expression of factors that restore protein folding homeostasis. However, in the liver and kidney, ER stress also leads to lipid accumulation, accompanied at least in the liver by transcriptional suppress...
2017-06-23 | MTBLS472 | MetaboLights
TranscriptomicsExpression analysis of the glucose deprivation-induced human tumor cell responses
The tumor microenvironment is characterized by low glucose and hypoxia. It is well known that changes in the tumor microenvironment, such as hypoxia and low glucose, can increase the production of VEGF. Although the role of hypoxia in the regulation of VEGF production is well understood, the mechani...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-38583 | biostudies-arrayexpress
TranscriptomicsAnalysis of the IRE1/XBP1 unfolded protein response (UPR) pathway in Schmid metaphyseal chondrodysplasia hypertrophic chondrocyte endoplasmic reticulum (ER) stress
We set out to determine the role of the IRE1/XBP1 pathway, the most ancient and highly conserved endoplasmic reticulum (ER) stress-sensing pathway of the unfolded protein response (UPR), in Schmid metaphyseal chondrodysplasia (MCDS). RNA derived from hypertrophic zones microdissected from growth pla...
ORGANISM(S): Mus musculus 
2015-08-21 | E-GEOD-72261 | biostudies-arrayexpress
TranscriptomicsOxidative stress induces mitochondrial dysfunction and a protective unfolded protein response in RPE cells
How retinal pigmented epithelial (RPE) cells degenerate from oxidative stress in age-related macular degeneration (AMD) is incompletely understood. The study's intent was to identify key cytoprotective pathways activated by oxidative stress, and to determine the extent of their protection. Immunohis...
ORGANISM(S): Homo sapiens 
2014-01-30 | E-GEOD-49107 | biostudies-arrayexpress
TranscriptomicsA dynamic unfolded protein response contributes to the control of cortical neurogenesis
The cerebral cortex contains layers of neurons sequentially generated by distinct lineage-related progenitors. At the onset of corticogenesis, the first-born progenitors are apical progenitors (APs) whose asymmetric division give birth directly to neurons. Later, they switch to indirect neurogenesis...
ORGANISM(S): Mus musculus 
2015-12-11 | E-GEOD-74683 | biostudies-arrayexpress
ProteomicsChronic lymphocytic leukaemia cells exhibit functional heterogeneity in the unfolded protein response: a proteomic study
Genomic, epigenomic, and transcriptomic studies have provided only a partial explanation of disease heterogeneity in chronic lymphocytic leukaemia (CLL). Since mRNA and protein expression do not always correlate, CLL heterogeneity was investigated using global cellular proteomics. Sequential Window...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD058183 | Pride
Chronic lymphocytic leukaemia Disease heterogeneity Response to therapy Unfolded protein response 
ProteomicsDissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma using Data-Independent Acquisition
Cells rely on the Unfolded Protein Response (UPR) to maintain ER homeostasis (proteostasis) when faced with elevated levels of misfolded and aggregated proteins, which can hinder the secretion of properly folded proteins. The UPR is composed of three main branches—ATF6, IRE1, and PERK—that coordinat...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD061073 | Pride
Proteomics automation Activating transcription factor 6 Data-independent acquisition (dia) Inositol requiring enzyme 1 Protein kinase r-like er kinase Unfolded protein response 
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