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TranscriptomicsLoss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents.
The nematode Caenorhabditis elegans has been used extensively to study responses to DNA damage. In contrast, little is known about DNA repair in this organism. C. elegans is unusual in that it encodes few DNA glycosylases and the uracil-DNA glycosylase (UDG) encoded by the ung-1 gene is the only kno...
ORGANISM(S): Caenorhabditis elegans 
2010-06-08 | E-GEOD-21467 | biostudies-arrayexpress
TranscriptomicsUNG shapes the specifity of AID-induced somatic hypermutation in non B cells
Secondary diversification of antibodies through somatic hypermutation (SHM) and class switch recombination (CSR) is a critical component of the immune response. Activation-induced deaminase (AID) initiates both processes by deaminating cytosine residues in immunoglobulin genes. The resulting U:G mis...
ORGANISM(S): Mus musculus 
2012-07-04 | E-GEOD-39108 | biostudies-arrayexpress
TranscriptomicsUNG shapes the specifity of AID-induced somatic hypermutation in B cells
Secondary diversification of antibodies through somatic hypermutation (SHM) and class switch recombination (CSR) is a critical component of the immune response. Activation-induced deaminase (AID) initiates both processes by deaminating cytosine residues in immunoglobulin genes. The resulting U:G mis...
ORGANISM(S): Mus musculus 
2012-07-04 | E-GEOD-39114 | biostudies-arrayexpress
TranscriptomicsUNG shapes the specificity of AID-induced somatic hypermutation
This SuperSeries is composed of the following subset Series: GSE39108: UNG shapes the specifity of AID-induced somatic hypermutation in non B cells GSE39114: UNG shapes the specifity of AID-induced somatic hypermutation in B cells Refer to individual Series
ORGANISM(S): Mus musculus 
2012-07-04 | E-GEOD-39115 | biostudies-arrayexpress
GenomicsUracil DNA glycosylase (UNG) loss enhances DNA double strand break formation in human cancer cells exposed to pemetrexed
To test the effects of uracil DNA glycosylase (UNG) loss on the formation of double strand breaks (DSBs) by the anti-cancer agent pemetrexed, we performed ChIP-seq for serine 139-phosphorylated H2AX (gammaH2AX), a marker of DSBs, in human cells wild-type or deficient for UNG in combination with peme...
ORGANISM(S): Homo sapiens 
2013-10-28 | E-GEOD-50692 | biostudies-arrayexpress
TranscriptomicsLoss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents.
The nematode Caenorhabditis elegans has been used extensively to study responses to DNA damage. In contrast, little is known about DNA repair in this organism. C. elegans is unusual in that it encodes few DNA glycosylases and the uracil-DNA glycosylase (UDG) encoded by the ung-1 gene is the only kno...
ORGANISM(S): Caenorhabditis elegans 
2010-05-26 | GSE21467 | GEO
UnknownUracil-DNA Glycosylase UNG Promotes Tet-mediated DNA Demethylation.
Not available
S-EPMC4705393 | biostudies-literature
GenomicsUracil DNA glycosylase (UNG) loss enhances DNA double strand break formation in human cancer cells exposed to pemetrexed
To test the effects of uracil DNA glycosylase (UNG) loss on the formation of double strand breaks (DSBs) by the anti-cancer agent pemetrexed, we performed ChIP-seq for serine 139-phosphorylated H2AX (gammaH2AX), a marker of DSBs, in human cells wild-type or deficient for UNG in combination with peme...
ORGANISM(S): Homo sapiens 
2013-10-28 | GSE50692 | GEO
UnknownGermline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.
Not available
S-EPMC3401444 | biostudies-literature
ProteomicsTime-resolved analysis of vUNG phosphorylation
Time-resolved phosphoproteomic analysis of HEp-2 cells infected with wild type HSV-1(F)
ORGANISM(S): Cellular Organisms 
2025-06-03 | PXD055199 | JPOST Repository
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