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TranscriptomicsA five-microRNA-signature predicting recurrence in HNSCC
The risk of locoregional or distant failure in advanced HPV-negative head and neck squamous cell carcinoma (HNSCC) patients is high. However, no suitable markers for stratification are clinically available. Thus, we aimed to identify a microRNA(miRNA)-signature predicting disease recurrence. For thi...
ORGANISM(S): Homo sapiens 
2018-09-06 | E-MTAB-5793 | biostudies-arrayexpress
TranscriptomicsWolf_et_al
Metabolic activation of CD8+ and NKT-cells causes NASH and HCC through cross-talk with hepatocytes. Mice that devloped HCC or NASH were compared to work out genomic differences of the two diseases. In order to characterise the importance of CCR2 (activation of monocytes) in the development of NASH a...
ORGANISM(S): Mus musculus 
2014-06-01 | E-MTAB-2469 | biostudies-arrayexpress
TranscriptomicsEctopic lymphoid structures as microniches for tumor progenitor cells
Genomic copy number profiling of hepatocellular carcinomas (HCC) from IKKβ(EE)Hep mice (C57BL/6) constitutively expressing IKKβ in the liver without and after treatment with DEN (diethylnitrosamine) and of HCCs that developed in wild type mice (C57BL/6) after DEN treatment.
ORGANISM(S): Mus musculus musculus x M. m. domesticus 
2015-09-25 | E-MTAB-3848 | biostudies-arrayexpress
ProteomicsMitochondrial damage drives T-cell immunometabolic paralysis after major surgery
Cytotoxic T cell (CTL) dysfunction is a key feature of immune paralysis following major surgery, significantly increasing the risk of severe nosocomial infections and contributing to elevated mortality in critically ill patients. The pathomechanisms of CTL dysfunction remain unclear. We report that ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-02-04 | MSV000097035 | MassIVE
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