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UnknownAging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice.
Not available
S-EPMC4204615 | biostudies-literature
UnknownEndothelial dysfunction and angiogenesis impairment in the ageing vasculature.
Not available
S-EPMC6612360 | biostudies-literature
UnknownYoung blood-mediated cerebromicrovascular rejuvenation through heterochronic parabiosis: enhancing blood-brain barrier integrity and capillarization in the aged mouse brain.
Not available
S-EPMC11336025 | biostudies-literature
UnknownSpatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain.
Not available
S-EPMC9135953 | biostudies-literature
UnknownCirculating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood.
Not available
S-EPMC7205954 | biostudies-literature
UnknownNicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment.
Not available
S-EPMC6885080 | biostudies-literature
TranscriptomicsResveratrol Diet Aging (Heart, Liver, Muscle and Fat Tissue)
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and others ha...
ORGANISM(S): Mus musculus 
2008-08-04 | E-GEOD-11845 | biostudies-arrayexpress
UnknownMeasurements of cerebral microvascular blood flow, oxygenation, and morphology in a mouse model of whole-brain irradiation-induced cognitive impairment by two-photon microscopy and optical coherence tomography: evidence for microvascular injury in the cerebral white matter.
Not available
S-EPMC10400746 | biostudies-literature
UnknownThe Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging.
Not available
S-EPMC10828351 | biostudies-literature
TranscriptomicsSRT1720 extends healthspan and lifespan in diet-induced obese mice
Activation of Sirt1, the mammalian homolog of an NAD+-dependent deacetylase known to modulate lifespan in lower organisms, is thought to hold promise as a strategy for delaying aging in mammals. SRT1720, a novel compound developed as a specific and potent activator of Sirt1, has shown promising effe...
ORGANISM(S): Mus musculus 
2011-08-17 | E-GEOD-19102 | biostudies-arrayexpress
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