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TranscriptomicsTranscription profiling of human Chronic Lymphocytic Leukemia cells with mutated and unmutated IGHV
High Expression of Lymphocyte-Activation Gene 3 in Chronic Lymphocytic Leukemia Cells is Associated with Unmutated IGHV and Reduced Treatment-Free Survival
ORGANISM(S): Homo sapiens 
2009-09-17 | E-TABM-696 | biostudies-arrayexpress
ProteomicsProteomic and Phosphoproteomic Signatures of Disease Progression in Unmutated IGHV Chronic Lymphocytic Leukemia
Chronic lymphocytic leukemia (CLL) patients with an unmutated (UM) immunoglobulin heavy chain variable region gene (IGHV) typically have poorer prognosis and require earlier treatment compared to those with mutated IGHV. Nevertheless, disease progression among UM-CLL patients is heterogeneous, with ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD072006 | Pride
Phosphoproteomics Chronic lymphocytic leukemia Disease progression Unmutated ighv Proteomics 
TranscriptomicsGene expression profile after dexamethasone in chronic lymphocytic leukemia cells according to IGHV/ZAP-70 status
Glucocorticoids are part of the therapeutic armamentarium of chronic lymphocytic leukemia where it has been suggested that cells with unmutated IGHV genes exhibit higher sensitivity. The mechanisms by which glucorticoids are active in CLL are not well elucidated. We used microarrays to detail the gl...
ORGANISM(S): Homo sapiens 
2012-12-04 | E-GEOD-33135 | biostudies-arrayexpress
Methylation profilingMethylation Profiling of IGHV Unmutated vs mutated CLL
In the present study, the methylation profiling (MeDIP) was carried out in 14 treatment-naive, early stage (Rai stage 0-2) CLL patients and pooled 19+ normal controls. To find an association of methylation with IGHV mutation status, CLL patients were further segregated into IGHV unmutated (n=9) and ...
ORGANISM(S): Homo sapiens 
2017-05-29 | GSE81936 | GEO
TranscriptomicsGene Expression profiling in IGHV Unmutated vs mutated CLL
In the present study, the gene expression profiling was carried out in 21 early stage CLL patients. A gene expression signature was generated for CLL patients as compared to normal controls; CLL patients were further seggregated into IGHV unmutated (n=10) and IGHV mutated (n=11) subgroups. The expre...
ORGANISM(S): Homo sapiens 
2017-05-29 | GSE81935 | GEO
TranscriptomicsMantle Cell Lymphoma
Gene expression analyis of primary MCL including IGHV mutated and unmutated cases Gene set analysis was perfomed in MCL samples, comparing IGHV mutated cases vs. IGHV unmutated cases In total 38 MCL samples were processed with the HU133plus 2.0 microarray. Twenty four cases had a IGHV mutations and...
ORGANISM(S): Homo sapiens 
2013-06-25 | E-GEOD-36000 | biostudies-arrayexpress
UnknownSimvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells.
Not available
S-EPMC4745766 | biostudies-literature
ProteomicsCLL iTRAQ1 - Total proteome analysis identifies migration defects as a major pathogenetic factor in immunoglobulin heavy chain variable region (IGHV)-unmutated chronic lymphocytic leukemia
The mutational status of the immunoglobulin heavy chain variable region (IGHV) defines two clinically distinct forms of chronic lymphocytic leukemia (CLL) known as mutated (M-CLL) and un-mutated (UM-CLL). To elucidate the molecular mechanisms underlying the adverse clinical outcome associated with U...
ORGANISM(S): Homo sapiens (Human) 
2016-06-27 | PXD001512 | Pride
Human Leukemia Itraq Mutation 
ProteomicsCLL iTRAQ2 - Total proteome analysis identifies migration defects as a major pathogenetic factor in immunoglobulin heavy chain variable region (IGHV)-unmutated chronic lymphocytic leukemia
The mutational status of the immunoglobulin heavy chain variable region (IGHV) defines two clinically distinct forms of chronic lymphocytic leukemia (CLL) known as mutated (M-CLL) and un-mutated (UM-CLL). To elucidate the molecular mechanisms underlying the adverse clinical outcome associated with U...
ORGANISM(S): Homo sapiens (Human) 
2016-06-27 | PXD001515 | Pride
Human Leukemia Itraq Mutation 
ProteomicsCLL iTRAQ3 - Total proteome analysis identifies migration defects as a major pathogenetic factor in immunoglobulin heavy chain variable region (IGHV)-unmutated chronic lymphocytic leukemia
The mutational status of the immunoglobulin heavy chain variable region (IGHV) defines two clinically distinct forms of chronic lymphocytic leukemia (CLL) known as mutated (M-CLL) and un-mutated (UM-CLL). To elucidate the molecular mechanisms underlying the adverse clinical outcome associated with U...
ORGANISM(S): Homo sapiens (Human) 
2016-06-27 | PXD001516 | Pride
Human Leukemia Itraq Mutation 
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