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ProteomicsUncover New Reactivity of Genetically Encoded Alkyl Bromide Unnatural Amino Acids
Genetically encoded unnatural amino acids (Uaas) with electrophilic moieties are excellent tools to investigate protein-protein interactions (PPIs) both in vitro and in vivo. These Uaas, including a series of alkyl bromide-based Uaas, mainly target cysteine residues to form protein-protein cross-lin...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-04-04 | PXD031159 | Pride
Chemical cross-linking And sumo interactome Unnatural amino acid Protein-protein interactions Genetic code expansion 
UnknownA remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids.
Not available
S-EPMC3984412 | biostudies-literature
UnknownUnnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C.
Not available
S-EPMC3962583 | biostudies-literature
ProteomicsMachine learning-guided evolution of pyrrolysyl-tRNA synthetase for improved incorporation efficiency of diverse noncanonical amino acids
The pyrrolysyl-tRNA synthetase (PylRS) is widely used to incorporate noncanonical amino acids (ncAAs) into proteins. However, most of ncAA-containing protein yields remain low due to the limited activity of PylRS variants. Here, we apply machine learning (ML) to engineer the tRNA-binding domain of P...
ORGANISM(S): Escherichia coli 
2025-07-25 | PXD065336 | Pride
Lc-ms Sfgfp Noncanonical amino acids 
UnknownTransferability of N-terminal mutations of pyrrolysyl-tRNA synthetase in one species to that in another species on unnatural amino acid incorporation efficiency.
Not available
S-EPMC7822784 | biostudies-literature
UnknownPredicting the structures of cyclic peptides containing unnatural amino acids by HighFold2.
Not available
S-EPMC12066415 | biostudies-literature
UnknownEnzymatic aminoacylation of tRNA with unnatural amino acids.
Not available
S-EPMC1450175 | biostudies-literature
UnknownLight Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids.
Not available
S-EPMC7293202 | biostudies-literature
UnknownDevelopment of mammalian cell logic gates controlled by unnatural amino acids.
Not available
S-EPMC9017196 | biostudies-literature
TranscriptomicsGenetic code expansion in stable cell lines enables encoded chromatin modification
Genetically encoded unnatural amino acids provide powerful strategies for modulating the molecular functions of proteins in mammalian cells. However this approach has not been coupled to genome-wide measurements, because efficient unnatural amino acid incorporation is limited to readily transfect...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-73823 | biostudies-arrayexpress
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