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TranscriptomicsTemporal RNASeq of C. difficile cultured within synthetic multispecies biofilm relative to C. difficile monoculture biofilms.
This experiment was performed largely to capture the dynamic transcriptional changes occurring in C. difficile when cultured within a 9 species synthetic gut communal consortium over a 48 h time series when cultured as a biofilm in vitro.
ORGANISM(S): Clostridioides difficile 
2026-09-23 | E-MTAB-15646 | biostudies-arrayexpress
MetabolomicsResolving coral photoacclimation dynamics through coupled photophysiological and metabolomic profiling
Corals continuously adjust to short term variation in light availability on shallow reefs. Long-term light alterations can also occur due to natural and anthropogenic stressors, as well as management interventions such as coral transplantation. Although short term photophysiological responses are re...
2019-04-11 | MTBLS768 | MetaboLights
ProteomicsBacteroides-driven metabolic remodelling suppresses Clostridioides difficile toxin expression in mixed biofilm communities
Clostridioides difficile is a major cause of hospital-associated diarrhoea worldwide. The intricate interactions between C. difficile and the resident gut microbiota play a crucial role in determining the outcome of C. difficile infection (CDI), although the molecular mechanisms underlying many C. d...
ORGANISM(S): Phocaeicola dorei CL02T00C15 
2026-10-15 | PXD068536 | Pride
Bacteroides Warwick_rtp Clostridioides difficile Microbiota Stickland fermentation Toxin a Biofilm 
UnknownChanges in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study.
Not available
S-EPMC8041365 | biostudies-literature
TranscriptomicsTranscriptomic profile of a Clostridioides difficile rsbW deletion mutant compared to parental R20291 strain
RNA-seq was conducted to uncover the regulatory roles of RsbW in the lifestyle of Clostridioides difficile strain R20291. RNA were extracted from planktonic cultures, which were grown in BHI-S (Sigma-Aldrich, USA) to early stationary phase (10h). The cells were re-suspended in LETS buffer and lysed...
ORGANISM(S): Clostridioides difficile 
2022-08-22 | E-MTAB-12114 | biostudies-arrayexpress
UnknownHospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study.
Not available
S-EPMC8397301 | biostudies-literature
UnknownRecurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7.
Not available
S-EPMC8185188 | biostudies-literature
ProteomicsThe type VII secretion system protects Staphylococcus aureus against host-specific fatty acids
The Staphylococcus aureus type VII secretion system (T7SS) exports several proteins that are pivotal for bacterial virulence. The mechanisms underlying T7SS-mediated staphylococcal survival during infection are nevertheless unclear. Here we show that EsxC, a small secreted effector implicated in bac...
ORGANISM(S): Staphylococcus aureus 
2021-09-08 | PXD013081 | Pride
Type vii secretion system Staphylococcus aureus Long-chain unsaturated free fatty acids 
UnknownClostridioides difficile LuxS mediates inter-bacterial interactions within biofilms.
Not available
S-EPMC6616478 | biostudies-literature
TranscriptomicsBacteroides (Phocaeicola)-driven metabolic remodelling suppresses Clostridioides difficile toxin expression in mixed biofilm communities
The aim of this study was to investigate transcriptomic changes in Clostridioides difficile when cultured as monoculture biofilms or as co-culture biofilms with either Bacteroides (Phocaeicola) dorei or Bacteroides (Phocaeicola) vulgatus. This study was also interested in transcriptomic changes occu...
ORGANISM(S): Phocaeicola vulgatus 
2026-09-23 | E-MTAB-15641 | biostudies-arrayexpress
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