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MetabolomicsGiardiavirus infection mediates Enolase to the upregulation of Glycolysis in Giardia

Giardia duodenalis is a prevalent intestinal parasite that cause giardiasis, a condition characterized by diarrhea and frequently linked to malnutrition and growth impairments in children. The presence of Giardiavirus (GLV) can lead to reduced pathological damage in mice infected with Giardia and...

2025-07-05 | MTBLS12615 | MetaboLights
MetabolomicsFungus Rhizopus microsporus var. rhizopodiformis Promotes Hepatic Steatosis via Upregulation of Hepatic Neutrophil Degranulation

Objective:

Metabolic associated fatty liver disease (MAFLD) affects approximately 25% of the global population, posing a serious threat to public health, and its pathogenesis remains largely unknown. Gut fungi play a significant role in the development of liver diseases, but the gut microbi...

2025-12-01 | MTBLS13120 | MetaboLights
MetabolomicsFungus Rhizopus microsporus var. rhizopodiformis Promotes Hepatic Steatosis via Upregulation of Hepatic Neutrophil Degranulation

Objective:

Metabolic associated fatty liver disease (MAFLD) affects approximately 25% of the global population, posing a serious threat to public health, and its pathogenesis remains largely unknown. Gut fungi play a significant role in the development of liver diseases, but the gut microbi...

2026-01-17 | MTBLS13705 | MetaboLights
MetabolomicsClostridium butyricum-induced ω-3 fatty acid 18-HEPE elicits anti-influenza virus pneumonia effects through interferon-λ upregulation

The precise mechanism by which butyrate-producing bacteria in the gut contribute to resistance to respiratory viral infections remains to be elucidated. Here, we describe a gut-lung axis mechanism and report that orally administered Clostridium butyricum (CB) enhances influenza virus infection re...

2023-05-30 | MTBLS4590 | MetaboLights
ProteomicsOsteomacs promote maintenance of murine hematopoiesis through megakaryocyte-induced upregulation of Embigin and CD166
Maintenance of hematopoietic stem cell (HSC) function in the niche is an orchestrated event. Osteomacs (OM), are key cellular components of the niche. Previously, we documented that osteoblasts, OM, and megakaryocytes interact to promote hematopoiesis. Here, we further characterize OM and identify m...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-01-11 | MSV000093840 | MassIVE
TranscriptomicsUpregulation of FOXM1 Induces Genomic Instability in Human Epidermal Keratinocytes
Genome-wide 10k SNP profiling of FOXM1B-transduced N/TERT and primary normal human epidermal keratinocytes (NHEK). The aim of this study was to study the cancer initiation role of UVB and FOXM1B upregulation in NHEK. Upregulation of FOXM1B alone (without UVB) was found to directly induce genomic ins...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-16937 | biostudies-arrayexpress
ProteomicsSegmental X-chromosome monosomies are compensated by transcriptional upregulation.
XX mice undergo both X-chromosome inactivation (XCI) and X-chromosome upregulation (XCU) to balance X-linked gene dosage with autosomes and XY mice. XCU has also been reported in XY cells, as well as cells with a single copy of the X-chromosome (XO). The two dosage compensation processes have been s...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-19 | PXD057399 | Pride
X-chromosome upregulation (xcu) Transcription X-chromosome X-chromosome inactivation (xci) 
ProteomicsUpregulation of protein O-GlcNAcylation levels promotes zebrafish fin regeneration
LC-MS/MS was performed to identify O-GlcNAc-glycoproteins. The results demonstrated that the O-GlcNAc glycoproteins
ORGANISM(S): Danio Rerio 
2025-02-22 | PXD059799 |
GenomicsMammalian X upregulation
Mammalian X upregulation
PRJNA144109 | ENA
TranscriptomicsGlobal Profiling in Vestibular Schwannomas Shows Critical Deregulation of MicroRNAs and Upregulation in those included in Chromosomal Region 14q32
Background: Vestibular Schwannomas are benign tumors that arise from Schwann cells in the VIII cranial pair and usually present NF2 gene mutations and/or loss of heterozygosity on chromosome 22q. Deregulation has also been found in several genes, such as ERBB2 and NRG1. MicroRNAs are non-coding RNAs...
ORGANISM(S): Homo sapiens 
2014-03-24 | E-GEOD-43571 | biostudies-arrayexpress
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