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MetabolomicsMulti-omics analysis identifies a microbiota–bile acid–TLR signaling axis driving bladder injury in interstitial cystitis

Hunner-type interstitial cystitis/bladder pain syndrome (HIC) is a complex and clinically challenging chronic disorder characterized by bladder-centered symptoms, including persistent pelvic pain and urinary urgency frequency, with elusive pathogenesis involving poorly defined multi-system intera...

2025-12-16 | MTBLS13513 | MetaboLights
MetabolomicsMulti-omics analysis identifies a microbiota–bile acid–TLR signaling axis driving bladder injury in interstitial cystitis

Hunner-type interstitial cystitis/bladder pain syndrome (HIC) is a complex and clinically challenging chronic disorder characterized by bladder-centered symptoms, including persistent pelvic pain and urinary urgency frequency, with elusive pathogenesis involving poorly defined mult...

2025-12-16 | MTBLS13512 | MetaboLights
TranscriptomicsLrig2 is required for maturation of peripheral nerves in the urinary bladder
Leucine-rich-repeats and immunoglobulin-like-domains (LRIG2) variants can occur in urofacial syndrome (UFS), an inherited disease characterised by functional bladder outlet obstruction. We aimed to define the pathobiology underlying UFS which we hypothesised would illuminate how the bladder becomes ...
ORGANISM(S): Mus musculus 
2020-04-27 | E-MTAB-6089 | biostudies-arrayexpress
Metabolomics1H HRMAS NMR Spectroscopy based Metabolomics of Urinary Bladder Tissues from NMIBC Patients
Not available
ORGANISM(S): Homo sapiens 
ST001737 | MetabolomicsWorkbench
MetabolomicsGut microflora alleviate immune response during E.coli-induced bladder cystits via AhR/MANF activation

In recent years, with the deepening of research on intestinal microbiota, we found intestinal microbiota plays an important role in host immune regulation and barrier maintenance through cross-talk between the microbiota and the host. New evidence suggests that disruption of the fragile balance w...

2023-07-11 | MTBLS5572 | MetaboLights
MetabolomicsHarnessing microbial-derived metabolites in the urinary tract to prevent infection induced catheter encrustation

Proteus mirabilis is a predominant cause of catheter associated urinary tract infection (CAUTI), and a key virulence factor is its urease enzyme which hydrolyzes urea to ammonia. This process results in the formation of urinary stones, facilitating catheter blockage and bacteremia. The o...

2025-08-29 | MTBLS891 | MetaboLights
TranscriptomicsTranscription profiling of rat bladder after inoculation with bladder cancer cells
Rat bladder cancer cells (AY-27 cell line) were inoculated intravesically into syngeneic female Fischer rats. The bladder was analyzed by histology and Affymetrix GeneChips and compared to bladders from sham operated and normal rats.
ORGANISM(S): Rattus norvegicus 
2009-04-22 | E-MTAB-104 | biostudies-arrayexpress
TranscriptomicsExpression data from rat urinary bladder and non-glandular stomach tissue samples
Seven novel and potent Raf small molecule kinase inhibitors were evaluated in 7-day oral repeat-dose rat toxicity studies. All compounds tested induced hyperplasia in multiple tissues. Microarrays were used to investigate transciptional changes associated by treatment with a single compound to gain ...
ORGANISM(S): Rattus norvegicus 
2011-07-18 | E-GEOD-26936 | biostudies-arrayexpress
TranscriptomicsExpression profile of non-muscle invasive (superficial) bladder carcinoma
Gene expression profiling of 82 human non-muscle invasive bladder carcinoma and 4 normal bladder samples, for a total of 86 tissues. A Cartes díIdentite des Tumeurs (CIT) study from the 'Institut Curie' and the french 'Ligue Nationale Contre le Cancer' (http://cit.ligue-cancer.net/).
ORGANISM(S): Homo sapiens 
2015-01-01 | E-MTAB-1940 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression profiling of urine and cancer tissues of patients with bladder cancer, and those from the controls with haematuria
Mid-stream urine was collected from bladder cancer patients prior to surgery. Both tumor tissue and normal bladder mucosa that are located at >3cm away from the tumor edge were obtained by cystoscopy. For the normal controls with haematuria, urine samples were collected from patients who had normal ...
ORGANISM(S): Homo sapiens 
2014-04-16 | E-MTAB-2573 | biostudies-arrayexpress
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