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MetabolomicsUrinary Extracellular Vesicle Metabolomic Profiling Reveals a Distinct Molecular Signature for the Non-Invasive Diagnosis of Lupus Nephritis

Background: Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE), underscoring an urgent need for non-invasive diagnostic biomarkers. 

Objective: This study aimed to define the metabolomic signature of urinary e...

2026-02-11 | MTBLS13839 | MetaboLights
MetabolomicsDivalent Aptamer-mediated Clustering for Extracellular Vesicle Separation
Extracellular vesicles (EVs) are important mediators of intercellular communication and promising sources of diagnostic and therapeutic biomarkers, yet effective EV isolation remains challenging due to trade-offs among yield, purity, and adaptability across biofluids. Here, we introduce divalent apt...
2026-05-04 | MTBLS14425 | MetaboLights
ProteomicsQuantitative proteomics and phosphoproteomics of urinary extracellular vesicles define putative diagnostic biosignatures for Parkinson’s disease
Background: Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been recognized as genetic risk factors for Parkinson’s disease (PD). However, compared to cancer, fewer genetic mutations contribute to the cause of PD, propelling the search for protein biomarkers for early detection of th...
ORGANISM(S): Homo Sapiens 
2024-11-02 | PXD032175 | panorama
GenomicsUrinary Extracellular Vesicle Whole-Transcriptome Analysis in Diabetic Nephropathy
Urinary Extracellular Vesicle Whole-Transcriptome Analysis in Diabetic Nephropathy
PRJNA906149 | ENA
ProteomicsInsights into the renal pathophysiology in Hermansky-Pudlak syndrome-1 from urinary extracellular vesicle proteomics and a new mouse model
Hermansky-Pudlak syndrome type 1 (HPS-1) is a rare, autosomal recessive disorder caused by defects in the biogenesis of lysosome-related organelles complex-3 (BLOC-3). Impaired kidney function is among its clinical manifestations. To investigate HPS-1 renal involvement, we employed 1D-gel-LC–MS/MS a...
ORGANISM(S): Homo sapiens (Human) 
2025-07-07 | PXD063765 | Pride
Proteomics Extracellular vesicles Renal pathology Hermansky-pudlak syndrome Tamm-horsfall protein 
TranscriptomicsRNA-Seq of Tissue, Plasma and Urinary Extracellular Vesicles of Prostate Cancer patients
We performed RNA-Seq analysis of plasma and urinary EVs collected before and after radical prostatectomy, and matched tumor and normal prostate tissues of 10 patients with prostate cancer. To identify putative cancer-derived RNA biomarkers, we searched for RNAs that were overexpressed in tumor as co...
ORGANISM(S): Homo sapiens 
2022-11-16 | E-MTAB-11910 | biostudies-arrayexpress
ProteomicsElucidation of urinary extracellular vesicle protein signatures from patients with cribriform and intraductal prostate carcinoma
A comprehensive systemic assessment of the proteome changes that occur in prostate cancer (PCa) during the onset and course of the illness may produce results that are clinically significant. Proteins, the main participants in the majority of biological events, are both potential biomarkers and ther...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD043874 | Pride
Intraductal prostate carcinoma Proteomics Cribriform Liquid chromatography mass spectrometry Urinary extracellular vesicles 
ProteomicsChanges in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies
Nephronophthisis is one of the leading genetic causes of end-stage renal disease in childhood. Early diagnostics and prognostics for nephronophthisis are currently limited. We aimed to identify non-invasive protein biomarkers for nephronophthisis in urinary extracellular vesicles. Extracellular vesi...
ORGANISM(S): Homo sapiens (Human) 
2018-08-06 | PXD009784 | Pride
Human Extracellular vesicle Label-free proteomics Nephronophthisis Kidney Ciliopathies 
ProteomicsThe proteomic landscape of small urinary extracellular vesicles during kidney transplantation
This study represents the first quantitative analysis of the temporal changes in the small urinary extracellular vesicle proteome throughout living donor kidney transplantation identifying PCK2 abundance as a biomarker for renal function 12 months after transplantation
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021344 | Pride
Temporal changes small urinary extracellular vesicle proteome 
TranscriptomicsMicroarray of neural progenitor cells from neonatal lung injury mice treated with placebo or umbilical-cord mesenchymal stromal cell extracellular vesicles or untreated, as well as age-matched control mice
The purpose of this experiment was to determine the transcriptional differences between neural progenitor cells from neonatal lung injury mice vs. control mice, as well as neonatal lung injury mice treated with umbilical-cord mesenchymal stromal cell extracellular vesicles vs. neonatal lung injury m...
ORGANISM(S): Mus musculus 
2022-05-17 | E-MTAB-11157 | biostudies-arrayexpress
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