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MetabolomicsThe Clinical Experiences of Urine Metabolomics of Genitourinary Urothelial Cancer in a Tertiary Hospital in Taiwan
There are few studies which have addressed the impact of diagnostic urine metabolites and clinical outcomes associated with genitourinary urothelial (GU) cancer till this date. Furthermore, the longitudinal analysis of the dynamics of urine metabolites contributing to the detection of GU cancer has ...
2021-07-28 | MTBLS2824 | MetaboLights
TranscriptomicsIntegrated genomic and gene expression profiling identifies two major gene/genomic circuits operating in urothelial carcinoma (gene expression)
Genomic and gene expression profiling identifies two major gene/genomic circuits operating in urothelial carcinoma 131 primary bladder cancer tumor samples were analyzed on Illumina gene expression Bead Arrays.
ORGANISM(S): Homo sapiens 
2012-06-17 | E-GEOD-32548 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic and gene expression profiling identifies two major gene/genomic circuits operating in urothelial carcinoma
This SuperSeries is composed of the following subset Series: GSE32535: Integrated genomic and gene expression profiling identifies two major gene/genomic circuits operating in urothelial carcinoma (genomic) GSE32548: Integrated genomic and gene expression profiling identifies two major gene/genomic ...
ORGANISM(S): Homo sapiens 
2012-06-17 | E-GEOD-32549 | biostudies-arrayexpress
TranscriptomicsA Molecular Taxonomy of Urothelial Carcinoma
Even though urothelial cancer (UC) is the fourth common tumor type among males, progress in treatment development has been deficient. Pathological assessment provides the urologists with only a broad classification, complicated by frequent disagreement among pathologist and the co-existence of diffe...
ORGANISM(S): Homo sapiens 
2012-05-23 | E-GEOD-32894 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic and gene expression profiling identifies two major gene/genomic circuits operating in urothelial carcinoma (genomic)
Genomic and gene expression profiling identifies two major gene/genomic circuits operating in urothelial carcinoma 146 primary bladder cancer tumor samples were analyzed on BAC array containing ~32 000 BAC clones. Arrays were produced at the Swegene Centre for Integrative Biology at Lund University ...
ORGANISM(S): Homo sapiens 
2012-06-17 | E-GEOD-32535 | biostudies-arrayexpress
TranscriptomicsDNA methylation analyses of urothelial carcinoma reveal distinct epigenetic subtypes and an association between gene copy number and methylation status
We assessed DNA methylation and copy number status of 27,000 CpGs in 149 urothelial carcinomas and integrated the findings with gene expression and mutation data. Methylation was associated with gene expression for 1,332 CpGs, of which 26% showed positive correlation with expression, i.e., high meth...
ORGANISM(S): Homo sapiens 
2012-08-31 | E-GEOD-33510 | biostudies-arrayexpress
TranscriptomicsDetailed analysis of 6p and 1q amplifications in urothelial carcinoma reveals SOX4 as an auxiliary target on 6p, and BCL9, CHDL1, MCL1, SETDB1, and HIF1B as putative targets on 1q.
Background: Previous array CGH analyses have revealed several recurring genomic alterations in urothelial carcinoma. The most common genomic amplifications occur at 6p22 and 1q21-24. The main target gene at 6p22 is believed to be E2F3. This gene is frequently co-amplified with CDKAL1 and SOX4 and th...
ORGANISM(S): Homo sapiens 
2013-08-30 | E-GEOD-40938 | biostudies-arrayexpress
TranscriptomicsReference Genes for MiRNAome Analysis of Urothelial Carcinomas
Background/Objective: Quantitative real-time PCR (RT-qPCR) is widely used in miRNA expression studies on cancer. To compensate for the analytical variability produced by the multiple steps of the method, relative quantification of the measured miRNAs is required, which is based on normalization to e...
ORGANISM(S): Homo sapiens 
2013-02-26 | E-GEOD-36121 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of human urothelial carcinoma cell lines RT-112, VM-Cub-1, SW1710, UMUC3 and a benign urothelial control HBLAK engineered to stably express HDAC5 against their vector control
Aberrant expression of histone deacetylases (HDACs) and their activity are associated with a broad range of tumor development. However, based on cell or tissue types, class IIA HDACs such as HDAC4 and HDAC5 may facilitate or inhibit cancer progression. The goal of this project is to examine the gene...
ORGANISM(S): Homo sapiens 
2019-11-13 | E-MTAB-8418 | biostudies-arrayexpress
TranscriptomicsSubtype classification, grading, and outcome prediction of urothelial carcinomas by combined mRNA profiling and aCGH
[original title] Combined gene expression and genomic profiling define two intrinsic molecular subtypes of urothelial carcinoma and gene signatures for molecular grading and outcome. In the present investigation we sought to refine the classification of urothelial carcinoma by combining information...
ORGANISM(S): Homo sapiens 
2010-06-14 | E-GEOD-19915 | biostudies-arrayexpress
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