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TranscriptomicsThe ShcA PTB Domain Functions as a Biological Sensor of Phospho-tyrosine Signaling During Breast Cancer Progression
The ShcA adaptor possesses two phosphotyrosine binding motifs, which include an SH2 and a PTB domain. In the majority of cases, ShcA utilizes its PTB domain to engage activated receptor tyrosine kinases (RTKs). To establish the mportance of this domain during mammary tumorigenesis, we employed a Sh...
ORGANISM(S): Mus musculus 
2013-08-07 | E-GEOD-41718 | biostudies-arrayexpress
TranscriptomicsShcA is a Paracrine Integrator of the Adaptive Immune Response during Breast Cancer Progression
Using transgenic mouse models of breast cancer, we demonstrate that loss of ShcA signaling within mammary tumors results in extensive CD4+ T cell infiltration, activation and induction of a humoral immune response. Our studies reveal that ShcA signaling during early breast cancer progression is requ...
ORGANISM(S): Mus musculus 
2010-10-12 | E-GEOD-18996 | biostudies-arrayexpress
TranscriptomicsThe prognostic ease and difficulty of invasive breast carcinoma
Breast carcinoma (BC) have been extensively profiled by high-throughput technologies for over a decade, and broadly speaking, these studies can be grouped into those that seek to identify patient subtypes (studies of heterogeneity) or those that seek to identify gene signatures with prognostic or pr...
ORGANISM(S): Homo sapiens 
2014-10-08 | E-GEOD-58644 | biostudies-arrayexpress
GenomicsValidation case-control serie (CC3) - samples
blood-based gene expression from breast cancer cases and age-matched controls in case-control serie 3 (CC3)
EGAD00010000478 | EGA
GenomicsPrimary case-control serie (CC1) - samples
blood-based gene expression from breast cancer cases and age-matched controls in case-control serie 1 (CC1)
EGAD00010000476 | EGA
GenomicsSecondary case-control serie (CC2) - samples
blood-based gene expression from breast cancer cases and age-matched controls in case-control serie 2 (CC2)
EGAD00010000474 | EGA
GenomicsNOWAC blood-based breast cancer case-control study
Tumor-host interactions extend beyond the local microenvironment and cancer development largely depends on the ability of malignant cells to hijack and exploit the normal physiological processes of the host. Although abnormalities in a host’s systemic immunity are associated with increased cancer ...
EGAS00000000134 | EGA
GenomicsNOWAC blood-breast cancer Data Access Committee
Data Access Committee EGAC01000000024
EGAC01000000024 | EGA
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