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TranscriptomicsTranscription profiling by array of human uterine fibroids with normal karyotype and 12q14~15 rearrangements
12q14~15 chromosomal rearrangements, specifically affecting the HMGA2 gene locus, are frequently observed in human uterine fibroids. Those fibroids are observed to show fast growth to a larger size compared to fibroids of normal karyotype. Since the HMGA2 gene is overexpressed, this study provides f...
ORGANISM(S): Homo sapiens 
2012-11-05 | E-MTAB-340 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human uterine fibroids and normal myometrium
Defects in mitochondrial enzymes predispose to severe developmental defects as well as tumorigenesis. Heterozygous germline mutations in the nuclear gene encoding fumarate hydratase (FH), an enzyme catalyzing the hydration of fumarate in the Krebs tricarboxylic acid cycle, cause hereditary leiomyoma...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-2724 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human uterine fibroids with mutated or wild type fumarate hydratase gene
A series of gene expression measurements of uterine fibroids with mutated or wild-type fumarate hydratase (FH) gene.
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-2152 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fibriods vs. normal myometrium with mutated or wild type fumarate hydratase (FH) gene reveals distinct expression profiles in fumarate-hydratase-deficient uterine fibroids.
A series of gene expression measurements of normal myometrium and uterine fibroids with mutated or wild-type fumarate hydratase (FH) gene.
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-2725 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Progesterone Receptor Binding: Cell Type-Specific and Shared Mechanisms in Uterine Fibroids and Breast Cancer (Expression BeadChip)
Analysis of genes regulated by RU486 (an progesterone antagonist) in human breast cancer T47D cells and human uterine leiomyoma smooth muscle cells. The hypothesis is that RU486 inhibits tumor growth by inactivating the transcription of multiple genes which trigger critical signaling pathways to ind...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-40725 | biostudies-arrayexpress
GenomicsGenome-Wide Progesterone Receptor Binding: Cell Type-Specific and Shared Mechanisms in Uterine Fibroids and Breast Cancer (ChIP-Seq)
Analysis of genes regulated by RU486 (an progesterone antagonist) in human breast cancer T47D cells and human uterine leiomyoma smooth muscle cells. The hypothesis is that RU486 inhibits tumor growth by inactivating the transcription of multiple genes which trigger critical signaling pathways to ind...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-40724 | biostudies-arrayexpress
ProteomicsA systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding
Uterine fibroids are benign tumours affecting up to 80% of women of reproductive age, with 30% of patients suffering severe symptoms including abnormal uterine bleeding, pain and infertility. Several studies have identified mutations in MED12 or HMGA2 that account for the vast majority of genomic ab...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD051220 | Pride
Uterine fibroids Proteomics 
TranscriptomicsTranscription profiling of human mayometrium and uterine fibroids with normal and non-normal karyotypes
Normal myometrium and uterine fibroids (partially paired from the same donor) were profiled. FISH analysis was used to analyze the karyotype of the uterine fibroid samples. This study provides further insights in the development of uterine fibroids. Additional uterine fibroid samples from the same s...
ORGANISM(S): Homo sapiens 
2023-07-01 | E-MTAB-12550 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human and rat uterine leiomyoma: identification of a dysregulated mTOR pathway
Uterine leiomyomata, or fibroids, are benign tumors of the uterine myometrium that significantly affect up to 30% of reproductive-age women. Despite being the primary cause of hysterectomy in the United States, accounting for up to 200,000 procedures annually, the etiology of leiomyoma remains large...
ORGANISM(S): Homo sapiens 
2009-09-05 | E-GEOD-13319 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Plexiform Leiomyomata provide further evidence for genetic heterogeneity underlying uterine fibroids
Plexiform leiomyomata are a histologically defined subgroup of benign uterine smooth muscle tumors based on their epitheliod cytology and abundant extracellular matrix. We used microarrays to compare plexiform leiomyomata to normal myometrium (smooth muscle of the uterine wall), typical leiomyomata,...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9511 | biostudies-arrayexpress
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