Sort   by:  
 Page size 
TranscriptomicsGenome-Wide Progesterone Receptor Binding: Cell Type-Specific and Shared Mechanisms in Uterine Fibroids and Breast Cancer (Expression BeadChip)
Analysis of genes regulated by RU486 (an progesterone antagonist) in human breast cancer T47D cells and human uterine leiomyoma smooth muscle cells. The hypothesis is that RU486 inhibits tumor growth by inactivating the transcription of multiple genes which trigger critical signaling pathways to ind...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-40725 | biostudies-arrayexpress
GenomicsGenome-Wide Progesterone Receptor Binding: Cell Type-Specific and Shared Mechanisms in Uterine Fibroids and Breast Cancer (ChIP-Seq)
Analysis of genes regulated by RU486 (an progesterone antagonist) in human breast cancer T47D cells and human uterine leiomyoma smooth muscle cells. The hypothesis is that RU486 inhibits tumor growth by inactivating the transcription of multiple genes which trigger critical signaling pathways to ind...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-40724 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human and rat uterine leiomyoma: identification of a dysregulated mTOR pathway
Uterine leiomyomata, or fibroids, are benign tumors of the uterine myometrium that significantly affect up to 30% of reproductive-age women. Despite being the primary cause of hysterectomy in the United States, accounting for up to 200,000 procedures annually, the etiology of leiomyoma remains large...
ORGANISM(S): Homo sapiens 
2009-09-05 | E-GEOD-13319 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Progesterone Receptor Binding: Cell Type-Specific and Shared Mechanisms in Uterine Fibroids and Breast Cancer
Analysis of genes regulated by RU486 (an progesterone antagonist) in human breast cancer T47D cells and human uterine leiomyoma smooth muscle cells. The hypothesis is that RU486 inhibits tumor growth by inactivating the transcription of multiple genes which trigger critical signaling pathways to ind...
ORGANISM(S): Homo sapiens 
2011-07-22 | E-GEOD-30871 | biostudies-arrayexpress
TranscriptomicsEpigenome analysis of uterin leiomyoma and myometrium with or without leiomyoma [Methylation data]
Profiles of genome-wide DNA methylation were investigated in leiomyomas and in myometrium with and without leiomyomas. Profiles of DNA methylation in the myometrium with and without leiomyomas were quite similar while those in leiomyomas were distinct. Bisulphite converted DNA from the three uterin...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-45187 | biostudies-arrayexpress
TranscriptomicsDifferences of miRNA expression profiling between GIST and leiomyoma tissue samples acquired by Tunneling Bloc Biopsy
miRNA expression profiling between GIST and leiomyoma specimens taken by Tunneling Bloc Biopsy Nine GIST patients and seven gastric leiomyoma patients underwent endoscopic biopsy called Tunnel Block Biopsy. MiRNAs were extracted from the tissues, then.
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-63453 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human uterine fibroids with normal karyotype and 12q14~15 rearrangements
12q14~15 chromosomal rearrangements, specifically affecting the HMGA2 gene locus, are frequently observed in human uterine fibroids. Those fibroids are observed to show fast growth to a larger size compared to fibroids of normal karyotype. Since the HMGA2 gene is overexpressed, this study provides f...
ORGANISM(S): Homo sapiens 
2012-11-05 | E-MTAB-340 | biostudies-arrayexpress
TranscriptomicsA High-dose of genistein down-regulates TGF-beta pathway genes in human uterine leiomyoma cells
High doses of genistein show an inhibitory effect on uterine leiomyoma (UtLM) cell proliferation. Using microarray analysis and Ingenuity Pathways AnalysisTM, we identified genes (up- or down-regulated, M-bM-^IM-%1.5 fold, P M-bM-^IM-$ 0.001), functions and signaling pathways that were altered follo...
ORGANISM(S): Homo sapiens 
2012-04-30 | E-GEOD-19477 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of uterine leiomyosarcoma (ULMS)
Uterine leiomyosarcoma (ULMS) is a poorly understood gynecologic cancer with few effective treatments. This study explores molecular events involved in ULMS with the goal of identifying strategies. Genome-wide transcriptional profiling were used to compare clinically well-annotated specimens of myom...
ORGANISM(S): Homo sapiens 
2012-04-26 | E-GEOD-36610 | biostudies-arrayexpress
TranscriptomicsExpression profiling of long noncoding RNAs and mRNAs in uterine leiomyoma
Global protein coding gene and miRNA expression profiling studies in uterine leiomyoma showed their aberrant expression and involvement in the pathogenesis of uterine leiomyoma. But the global expression patterns and potential clinical value of long noncoding RNA (lncRNA) in uterine leiomyoma have n...
ORGANISM(S): Homo sapiens 
2014-08-14 | E-GEOD-52618 | biostudies-arrayexpress
Sort   by:  
 Page size