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ProteomicsSpatial proteomics reveals profound subcellular reorganization in human keratinocytes exposed to UVA light
The effects of UV light on the skin have been extensively investigated. However, systematic information about how exposure to UVA light, the least energetic but the most abundant UV radiation reaching the Earth, shapes the subcellular organization of proteins is lacking. Using subcellular fractionat...
ORGANISM(S): Homo sapiens (Human) 
2022-03-06 | PXD027941 | Pride
Spatial proteomics Keratinocytes Uva light 
ProteomicsA single dose of Ultraviolet-A induces proteome remodeling and senescence in primary human keratinocytes
The UVB component of the sunlight (290-320 nm) plays an important role in carcinogenesis through generation of high levels of bipyrimidine DNA photoproducts, while UVA (320-400 nm) has been associated with photoaging and tumor progression through generation of low, but continuous levels of DNA damag...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025191 | Pride
Orbitrap fusion lumos Keratinocytes Hacat Nhek Uva light Shotgun Senescence 
TranscriptomicsGene expression profiling of human and dog breast cancers
Spontaneous tumors in dog have been demonstrated to share many features with their human counterparts, including relevant molecular targets, histological appearance, genetics, biological behavior and response to conventional treatments. Mammary tumors in dog therefore provide an attractive alternati...
ORGANISM(S): Canis lupus familiaris 
2010-06-25 | E-GEOD-14999 | biostudies-arrayexpress
MetabolomicsUntargeted LC-HRMS Based-Plasma Metabolomics Reveals 3-O-Methyldopa as a New Biomarker of Poor Prognosis in High-Risk Neuroblastoma
Neuroblastoma (NB) is the most common extracranial malignant tumor in children. Although the survival rate of NB has improved over the years, the outcome of NB still remains poor for over 30% of cases. A more accurate risk stratification remains a key point in the study of NB and the availability of...
2023-07-14 | MTBLS4294 | MetaboLights
TranscriptomicsGenotypic and Phenotypic Versatility of Aspergillus flavus during Maize Exploitation
Several are the inputs which are able to modulate mycotoxin synthesis. In particular, when a fungus receives an external stimulus reacts by activating, through a quite well-defined signal cascade, an evident switch in its lifestyle. This profound change is also due to the activation of global gene r...
ORGANISM(S): Aspergillus flavus 
2013-09-19 | E-GEOD-28163 | biostudies-arrayexpress
UnknownHow Genetics Might Explain the Unusual Link Between Malaria and COVID-19.
Not available
S-EPMC8107224 | biostudies-literature
TranscriptomicssVEGFR-1 signaling through α5β1 integrin
Soluble VEGFR-1 (sVEGFR-1) acts both as a decoy receptor for VEGFs and as an extracellular matrix protein for α5β1 integrin. A sVEGFR-1-derived peptide that interacts with α5β1 integrin promotes angiogenesis. However, canonical signal downstream integrin activation is not induced, resulting into...
ORGANISM(S): Homo sapiens 
2014-01-20 | E-GEOD-32560 | biostudies-arrayexpress
UnknownExosomal MicroRNAs as Potential Biomarkers of Hepatic Injury and Kidney Disease in Glycogen Storage Disease Type Ia Patients.
Not available
S-EPMC8745197 | biostudies-literature
TranscriptomicsA microarray analysis highlights the role of tetrapyrrole pathways in grapevine responses to stolbur phytoplasma, phloem virus infections and recovered status
Several systemic diseases affect Vitis vinifera worldwide with important consequent management costs. Phytoplasma and viruses represent the most detrimental pathogens inducing symptoms and metabolic alterations that modify quantitatively the crop production. In the aim to investigate the plant/patho...
ORGANISM(S): Vitis vinifera 
2016-02-19 | E-GEOD-52540 | biostudies-arrayexpress
TranscriptomicsMonozygotic twins discordant for recessive dystrophic epidermolysis bullosa phenotype highlight the role of TGF-β signalling in modifying disease severity
Recessive dystrophic epidermolysis bullosa (RDEB) is a genodermatosis characterized by fragile skin forming blisters that heal invariably with scars. It is due to mutations in the COL7A1 gene encoding type VII collagen, the major component of anchoring fibrils connecting the cutaneous basement membr...
ORGANISM(S): Homo sapiens 
2014-04-03 | E-GEOD-51056 | biostudies-arrayexpress
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