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MetabolomicsMetabolomics analysis revealed the effects of different treatments on the metabolic profile of HaCaT cells
To investigate the regulatory effects of the ECM@SF-AGS-CS-LA hydrogel (HC), exosomes (HB), and their combination (HA) on the metabolic profiles of wound tissues in diabetic mice, HaCaT keratinocytes were employed as an in vitro cellular model. Untargeted metabolomics profiling was performed on HaCa...
2026-05-14 | MTBLS14481 | MetaboLights
MetabolomicsResveratrol metabolism in HepG2 (human hepatocytes), HaCaT (human keratinocytes), and C2C12 (mouse myoblasts)
Resveratrol (RESV) is a plant polyphenol, which is thought to have beneficial metabolic effects in laboratory animals as well as in humans. Following oral administration, RESV is immediately catabolized, resulting in low bioavailability. This study compared RESV metabolites and their tissue distribu...
MTBLS127 | MetaboLights
TranscriptomicsInfluence of alkyl-phospholipids on the gene expression profile of immortalized keratinocytes HaCaT
New alkyl-phospholipids (APLs) that are structurally derived from the platelet-activating factor are promising candidates for anticancer treatment. After the incorporation into cell membranes, APLs are able to interfere with a wide variety of key enzymes implicated in cell growth, motility, invasion...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-20722 | biostudies-arrayexpress
ProteomicsHuman keratinocytes HaCaT LC-MS/MS
Triton X-100 has been used as a model substance to study the effects of irritants on the skin. HaCaT human keratinocyte cell line were treated with a non-cytotoxic dose of Triton X-100, as determined by the MTT assay and microscopically examination) for 48 h. The altered abundance of proteins from H...
ORGANISM(S): Homo sapiens (Human) 
2017-11-03 | PXD007776 | Pride
Hacat keratinocytes Shotgun proteomics Exposure Triton x-100 
ProteomicsHuman keratinocytes HaCaT LC-MSMS_SDS exposure
We employed human HaCaT cells as a model system to identify cellular proteins that accompany SDS-induced toxicity based on a proteomic approach. HaCaT human keratinocyte cell line were treated with a non-cytotoxic dose of SDS (25 µg/ml, as determined by the MTT assay and microscopically examination)...
ORGANISM(S): Homo sapiens (Human) 
2017-11-03 | PXD007789 | Pride
Hacat keratinocytes Shotgun proteomics Sodium dodecyl sulphate Exposure Pathview map Glycolysis/gluconeogenesis 
TranscriptomicsAberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide
The purpose of this study is to search for aberrant genes in HaCaT keratinocytes after chronic exposure to arsenic trioxide. The objective of the investigation was to discover the mechanism of arsenic carcinogenicity in human epidermal keratinocytes. We hypothesize that a combined strategy of DNA mi...
ORGANISM(S): Homo sapiens 
2012-04-11 | E-GEOD-37192 | biostudies-arrayexpress
TranscriptomicsTransfection of HaCaT cells with HPV11 HPV16 or HPV45 genome
We investigated the early stage of HPV infections by global expression profiling in a cell model, in which cells from the human keratinocyte cell line, HaCaT, were transfected with HPV11, HPV16 or HPV45 genomes ( methods used for transfection are described in PubMed ID: 21078297)
ORGANISM(S): Homo sapiens 
2012-07-01 | E-MTAB-1160 | biostudies-arrayexpress
TranscriptomicsExpression data from BCL-3 overexpression HaCat cells
Constitutive activation of EGFR- and NF-kB-dependent pathways is a hallmark of cancer, yet signaling proteins that connect both oncogenic cascades are poorly characterized. Here we define KIAA1199 as a BCL-3- and p65-dependent gene in transformed keratinocytes. KIAA1199 expression is enhanced upon h...
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-60551 | biostudies-arrayexpress
TranscriptomicssiRNA profiling of human HACAT cells treated with si RNA against Keap 1 or a scrambled si RNA sequence
Transcriptional profiling in HACAT cells using a whole human genome array; HACAT cells treated with si RNA against Keap 1 or a scrambled si RNA sequence (Scram) vs HACAT cells mock transfected with lipofectamine (reference control) Experiment Overall Design: 2 biological replicates, 2 technical (dye...
ORGANISM(S): Homo sapiens 
2009-09-04 | E-GEOD-17011 | biostudies-arrayexpress
ProteomicsTaxifolin protects HaCaT keratinocytes from UVB damage
The photoprotective efficacy and underlying mechanisms of taxifolin against UVB-induced injury were evaluated in human immortalized keratinocytes (HaCaT).
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD073279 | Pride
Taxifolin Proteome Hacat 
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