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TranscriptomicsRNA-seq of human uveal melanoma cell lines 92-1, MP41 and UM22 treated with entinostat, JQ1 or DMSO
As part of the preclinical research for a recently published trial of combination therapy with the HDAC inhibitor entinostat and the PD1 inhibitor pembrolizumab, an experiment was performed to determined the influence of entinostat and the BET inhibitor JQ1 on the transcriptome of three uveal melano...
ORGANISM(S): Homo sapiens 
2021-09-09 | E-MTAB-11058 | biostudies-arrayexpress
ProteomicsTargeting the CDS1/2 axis as a therapeutic strategy in uveal melanoma and pan-cancer
Metastatic uveal melanoma is an aggressive disease with limited effective therapeutic options. To comprehensively map monogenic and digenic dependencies, we performed CRISPR-Cas9 screening in ten extensively profiled human uveal melanoma cell line models using genome-wide single gene/gRNA and combin...
ORGANISM(S): Homo sapiens (Human) 
2025-04-01 | PXD053752 | Pride
Cds1 Cds2 Uveal melanom 
GenomicsRNAseq cutaneous and uveal melanoma liver metastases
RNA sequencing analyses of tumor liver metastases from untreated cutaneous melanoma (CM) and uveal melanoma (UM) patients.
EGAS00001004794 | EGA
GenomicsWES cutaneous and uveal melanoma liver metastases
Whole exome sequencing analyses of tumor liver metastases from untreated cutaneous melanoma (CM) and uveal melanoma (UM) patients.
EGAS00001004795 | EGA
GenomicsMolecular profiling of metastatic uveal melanoma
Metastatic uveal melanoma is less well understood than its primary counterpart, has a distinct biology compared to skin melanoma and lacks effective treatments. Here we genomically profile metastatic tumors and infiltrating lymphocytes. BAP1 alterations were overrepresented and occurred in 29/32 of ...
EGAS00001004296 | EGA
GenomicsGermline variants in patients diagnosed with both uveal and cutaneous melanoma
We sequenced the constitutional DNA from patients affected by both uveal and cutaneous melanoma.
EGAS00001007584 | EGA
Genomicsc659dd4f-a6ff-46cd-b6b4-d574f7803192 - samples
The dataset include sequencing data from 23 patients diagnosed with metastatic melanoma. The 23 metastatic melanoma subtypes consisted of cutaneous melanoma (CM, n=10); head and neck melanoma (HNM, n=7); uveal melanoma (UM, n=4); acral lentiginous (AM, n=1) and mucosal melanoma (MM, n=1).
EGAD00001008336 | EGA
GenomicsConcurrent germline and somatic pathogenic BAP1 variants in a patient with metastatic bladder cancer
Germline pathogenic variants in the BRCA1-associated protein-1 (BAP1) gene cause the BAP1-tumor predisposition syndrome (BAP1-TPDS). BAP1-TPDS is associated with an increased risk of uveal and cutaneous melanoma, mesothelioma, renal cell carcinoma, and several other cancer subtypes. Here, we report ...
EGAS00001004055 | EGA
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