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ProteomicsAncestral mechanism of Calmodulin binding to Cds1 kinase inhibits catalytic activity
SDA chemical crosslinking mass spectrometry was used to investigate the interaction between the Cds1 kinase and Ca2+-Calmodulin from Schizosaccharomyces pombe. Upon binding of Ca2+-Calmodulin, Cds1 is allosterically inhibited.
ORGANISM(S): Schizosaccharomyces pombe 
2026-09-14 | PXD070930 | Pride
Schizosaccharomyces pombe Calmodulin Calcium Cell cycle Cds1 kinase 
ProteomicsTargeting the CDS1/2 axis as a therapeutic strategy in uveal melanoma and pan-cancer
Metastatic uveal melanoma is an aggressive disease with limited effective therapeutic options. To comprehensively map monogenic and digenic dependencies, we performed CRISPR-Cas9 screening in ten extensively profiled human uveal melanoma cell line models using genome-wide single gene/gRNA and combin...
ORGANISM(S): Homo sapiens (Human) 
2025-04-01 | PXD053752 | Pride
Cds1 Cds2 Uveal melanom 
UnknownAutoinhibition and autoactivation of the DNA replication checkpoint kinase Cds1.
Not available
S-EPMC2708895 | biostudies-literature
UnknownNutrient Limitation Inactivates Mrc1-to-Cds1 Checkpoint Signalling in Schizosaccharomyces pombe.
Not available
S-EPMC5850103 | biostudies-literature
UnknownS-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe.
Not available
S-EPMC316487 | biostudies-literature
ProteomicsCDS2 is a synthetic lethal target in mesenchymal-like cancers
Synthetic lethal interactions (SLIs) based on genomic alterations in cancer have been therapeutically explored. We investigated the SLI space as a function of differential RNA expression in cancer and normal tissue. Computational analyses of functional genomic and gene expression resources uncovered...
ORGANISM(S): Homo sapiens (Human) 
2025-03-31 | PXD045833 | Pride
Synthetic lethal interactions Cds2 Dia Mesenchymal cancers Proteome Lc-ms/ms 
UnknownThe synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types.
Not available
S-EPMC12283370 | biostudies-literature
UnknownCritical role of Caenorhabditis elegans homologs of Cds1 (Chk2)-related kinases in meiotic recombination.
Not available
S-EPMC99585 | biostudies-literature
TranscriptomicsGenome-wide transcriptomic profiling of ramie (Boehmeria nivea (L.) Gaudich.) in response to cadmium stress
Cadmium (Cd)-contamination in soil has been becoming a major environmental problem in China. Ramie, a fiber crop, was frequently proposed to be used as the crop for phytoremediation of Cd-contaminated farmlands. However, high level Cd accumulation can cause a great inhibition of growth in ramie. To ...
ORGANISM(S): Boehmeria nivea 
2015-08-21 | E-GEOD-60583 | biostudies-arrayexpress
UnknownXenopus Cds1 is regulated by DNA-dependent protein kinase and ATR during the cell cycle checkpoint response to double-stranded DNA ends.
Not available
S-EPMC525475 | biostudies-literature
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