Sort   by:  
 Page size 
GenomicsThe In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci
The critical initial step in V(D)J recombination, binding of RAG1 and RAG2 to recombination signal sequences flanking antigen receptor V, D, and J gene segments, has not previously been characterized in vivo. Here we demonstrate that RAG protein binding occurs in a highly focal manner to a small reg...
ORGANISM(S): Mus musculus 
2010-04-19 | E-GEOD-21207 | biostudies-arrayexpress
GenomicsLig3 is the primary ligase in AEJ -mediated V(D)J recombination
Lig3 is the primary ligase in AEJ -mediated V(D)J recombination
PRJNA1096021 | ENA
GenomicsThe Fundamental Role of Chromatin Loop Extrusion in Physiological V(D)J Recombination [HTGTS V(D)J-seq]
The Fundamental Role of Chromatin Loop Extrusion in Physiological V(D)J Recombination [HTGTS V(D)J-seq]
PRJNA534316 | ENA
GenomicsATM and 53BP1 regulate alternative end joining-mediated V(D)J recombination
ATM and 53BP1 regulate alternative end joining-mediated V(D)J recombination
PRJNA1032082 | ENA
GenomicsRegulated the AEJ -mediated V(D)J recombination by 53BP1 and ATM
Regulated the AEJ -mediated V(D)J recombination by 53BP1 and ATM
PRJNA1015627 | ENA
ProteomicsNUDCD3 deficiency disrupts V(D)J recombination to cause SCID/Omenn syndrome
Inborn errors of T cell development present a pediatric emergency in which timely curative therapy is informed by molecular diagnosis. In 9 affected patients across 3 consanguineous kindreds, we detected homozygosity for a single deleterious missense variant in the gene NudC domain containing 3 (NUD...
ORGANISM(S): Homo sapiens (Human) 
2024-09-27 | PXD035840 | Pride
Pulldown Nudcd3 Proteomics Omenn syndrome 
TranscriptomicsOrientation-specific RAG activity in chromosomal loop domain contribute to Tcrd V(D)J recombination during T cell development
T cell antigen receptor δ (Tcrd) variable region exons are assembled by RAG-initiated V(D)J recombination. Here, we employ a high throughput method to map hundreds of thousands of RAG-initiated Tcrd D segment (Trdd1 and Trdd2) rearrangements in developing thymocytes. We find that Trdd2 joins direct...
ORGANISM(S): Mus musculus 
2016-08-04 | E-GEOD-79892 | biostudies-arrayexpress
GenomicsCharacterize compounds that affect V(D)J recombination and chromsomal translocation using MP-HTGTS
Characterize compounds that affect V(D)J recombination and chromsomal translocation using MP-HTGTS
PRJNA1015227 | ENA
GenomicsSHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination
SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination
PRJNA836576 | ENA
GenomicsContext-dependent regulation of IgH V(D)J recombination by cohesin-STAG1 and cohesin-STAG2 [HTGTS-V(D)J-Seq]
Context-dependent regulation of IgH V(D)J recombination by cohesin-STAG1 and cohesin-STAG2 [HTGTS-V(D)J-Seq]
PRJNA1256327 | ENA
Sort   by:  
 Page size