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MetabolomicsExogenous L-Alanine promotes phagocytosis multidrug-resistant bacterial pathogens (V. parahaemolyticus-infected spleen metabolomics)

Multidrug-resistant bacteria present a major threat to public health. Therefore, new drugs or approaches are urgently needed to manage and mitigate this threat. Here, we screen the molecular candidates that allow the survival of mice upon Vibrio parahaemolyticus infection by integrated p...

2024-09-26 | MTBLS7996 | MetaboLights
MetabolomicsGlucose potentiates florfenicol killing of antibiotic-resistant V. parahaemolyticus by enhancing proton motive force and reactive oxygen species

 Florfenicol is valued for its clinical safety, particularly its reduced bone marrow toxicity compared to other old antibiotics of chloramphenicols. However, the rise of bacterial resistance threatens its efficacy. To address this, we evolved a florfenicol-resistant strain of Vibrio par...

2025-10-14 | MTBLS13132 | MetaboLights
TranscriptomicsTranscriptome Analysis of T3SS1 in Vibrio parahaemolyticus
Comparative transcriptional mRNA profiles were generated of bacterial pathogen Vibrio parahaemolyticus under conditions that induce activity of virulence factor type III secretion system 1 (T3SS1). Induction conditions included growth of the bacteria in Dulbecco's Modified Eagle Medium (DMEM), over...
ORGANISM(S): Vibrio parahaemolyticus 
2014-01-21 | E-GEOD-51423 | biostudies-arrayexpress
ProteomicsEnvironmental conditions steer phenotypic switching in AHPND-causing Vibrio parahaemolyticus, affecting PirABVP toxin production
Bacteria in nature are widely exposed to differential fluid shears which are often a trigger for phenotypic switches. The latter mediates transcriptional and translation remodeling of cellular metabolism impacting among others virulence, antimicrobial resistance and stress resistance. In this study,...
ORGANISM(S): Vibrio parahaemolyticus 
2020-02-05 | PXD015617 | Pride
Virulence Biological features Vibrio parahaemolyticus Fluid shear Phenotype switching Antimicrobial resistance 
TranscriptomicsSurface sensing in Vibrio parahaemolyticus triggers a programme of gene expression that promotes colonization and virulence
Vibrio parahaemolyticus senses surfaces via impeded rotation of its polar flagellum. We have exploited this surface-sensing mechanism to trick the organism into thinking it is on a surface when it is growing in liquid. This facilitated studies of global gene expression in a way that avoided many of ...
ORGANISM(S): Vibrio parahaemolyticus 
2010-12-15 | E-GEOD-18763 | biostudies-arrayexpress
TranscriptomicsGenomic comparison in Vibrio parahaemolyticus strains by comparative genomic hybridization.
Vibrio parahaemolyticus is a Gram-negative marine bacterium. A limited population of the organisms causes acute gastroenteritis in humans. Almost all of the clinical V. parahaemolyticus isolates exhibit a beta-type hemolysis on Wagatsuma agar, known as the Kanagawa phenomenon (KP). KP is induced by ...
ORGANISM(S): Vibrio parahaemolyticus 
2010-05-25 | E-GEOD-10020 | biostudies-arrayexpress
TranscriptomicsQuorum sensing and silencing in Vibrio parahaemolyticus
The quorum regulatory cascade is poorly characterized in Vibrio parahaemolyticus, in part because swarming and pathogenicity - the hallmark traits of the organism - are repressed by this scheme of gene control. As a consequence, many isolates appear silenced for quorum sensing via phase variation. I...
ORGANISM(S): Vibrio parahaemolyticus 
2011-12-01 | E-GEOD-28216 | biostudies-arrayexpress
TranscriptomicsCalcium is a global regulator in Vibrio parahaemolyticus
Here we probe the global response to calcium in the marine bacterium and pathogen Vibrio parahaemolyticus by using transcriptome, reporter and phenotypic analyses. Swarming gene expression and motility were enhanced by calcium. Calcium also stimulated expression and function of one of the organism...
ORGANISM(S): Vibrio parahaemolyticus 
2010-11-05 | E-GEOD-22190 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of V. parahaemolyticus to Zn limitation.
RNA sequencing analysis of the transcriptome of V. parahaemolyticus RIMD2210633 strain grown under Zn-deficient (LB pretreated with 35 μM TPEN) and Zn-replete conditions (LB pretreated with 35 μM TPEN along with 500 μM Zn).
ORGANISM(S): Vibrio parahaemolyticus 
2022-04-24 | GSE200927 | GEO
TranscriptomicsOpaR Controls a Network of Downstream Transcription Factors in Vibrio parahaemolyticus BB22
Vibrio parahaemolyticus an emerging pathogen that is a causative agent of foodborne gastroenteritis when raw or undercooked seafood is consumed. Previous microarray data using a Vibrio parahaemolyticus RIMD2210633 chip has shown the master quorum-sensing regulator OpaR controls virulence, type III...
ORGANISM(S): Vibrio parahaemolyticus 
2013-12-31 | E-GEOD-53639 | biostudies-arrayexpress
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