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GenomicsBiomarkers for canine Leptospira vaccine potency
Biomarkers for canine Leptospira vaccine potency
PRJNA793869 | ENA
ProteomicsBiomarkers for canine Leptospira vaccine potency
Mandatory potency testing of Leptospira vaccine batches relies partially on in vivo procedures, requiring large numbers of laboratory animals. Cell-based assays could replace in vivo tests if biomarkers indicative of Leptospira vaccine potency are identified. We investigated innate immune responsive...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2022-03-06 | PXD031875 | Pride
Innate immunity Vaccine Monocyte Dog Biomarker Leptospira 
ProteomicsPeritoneal Cell-Derived Exosomes: Novel Mediators of T Cell Activation and Vaccine Potency in Fish
Exosomes are small extracellular vesicles that play significant roles in cell communication and immune modulation. When considering adaptive immunity, exosomes have been proposed to be involved in T and B cell development, antigen presentation, as well as the cross-presentation of antigens. While th...
ORGANISM(S): Paralichthys olivaceus 
2026-04-06 | PXD059066 | Pride
Vaccine potency Antibody response T-cell activation  fish Exosomes 
UnknownConcordance of in vitro and in vivo measures of non-replicating rotavirus vaccine potency.
Not available
S-EPMC9405915 | biostudies-literature
UnknownPotency testing for a recombinant protein vaccine early in clinical development: Lessons from the Schistosoma mansoni Tetraspanin 2 vaccine.
Not available
S-EPMC8209742 | biostudies-literature
TranscriptomicsBiomarkers for canine Leptospira vaccine potency
We used RNAseq to investigate innate immune responsiveness in canine 030-D cell line induced by inactivated L. interrogans serogroups Canicola and Icterohaemorrhagiae, and two bivalent, non-adjuvanted canine Leptospira vaccines containing the same serogroups. We identified more than 900 DEGs associa...
ORGANISM(S): Canis lupus 
2022-03-06 | GSE192945 | GEO
UnknownPotency of a thermostabilised chimpanzee adenovirus Rift Valley Fever vaccine in cattle.
Not available
S-EPMC4851241 | biostudies-literature
UnknownDevelopment and statistical validation of a guinea pig model for vaccine potency testing against Infectious Bovine Rhinothracheitis (IBR) virus.
Not available
S-EPMC7115698 | biostudies-literature
UnknownPhase 1 safety and immunogenicity trial of the Plasmodium falciparum blood-stage malaria vaccine AMA1-C1/ISA 720 in Australian adults.
Not available
S-EPMC2847846 | biostudies-literature
UnknownAnalysis of multiple Leptospira interrogans serovar Canicola vaccine proteomes and identification of LipL32 as a biomarker for potency.
Not available
S-EPMC3318284 | biostudies-literature
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