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TranscriptomicsA Model System for Studying the Transcriptomic and Physiological Changes Associated with Mammalian Host-Adaptation by Leptospira interrogans Serovar Copenhageni
Leptospirosis, an emerging zoonotic disease with worldwide distribution, is caused by spirochetes belonging to the genus Leptospira. More than 500,000 cases of severe leptospirosis are reported annually, with .10% of these being fatal. Leptospires can survive for weeks in suitably moist conditions b...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2014-03-20 | E-GEOD-53818 | biostudies-arrayexpress
ProteomicsProteomic analysis of extracellular proteins of Leptospira interrogans
Leptospira, the causative agent of leptospirosis is known to have several proteases with potential to degrade extracellular matrix. However, a multipronged approach to identify, classify, characterize and elucidate their role has not been attempted. In this study, we carried out in-depth proteomic a...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2022-02-17 | PXD026044 | Pride
Proteomics Ls-ms/ms Leptospira interrogans 
ProteomicsDissecting post-translational modifications in Leptospira proteome to elucidate novel insights into pathogen-host interaction using bioinformatics approach
Leptospirosis is a zoonotic disease caused by Leptospira spp. that cause serious health burden. Humans are accidental host gets infected from water contaminated with Leptospira from urine of reservoir hosts like rodents and other mammals. Currently there is no effective vaccine available for leptosp...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2022-08-12 | PXD030370 | Pride
Leptospira  protein modification  drug target  diagnosis  mass spectrometry  proteome discoverer 
ProteomicsCore–sheath coupling controls flagellar curvature and motility in Leptospira
Spirochete pathogens are among the most invasive bacteria known, causing syphilis, Lyme disease, and leptospirosis. Their tissue penetration depends on periplasmic flagellar filaments that, unlike other bacterial flagella, are encased in a spirochete-specific multi-protein sheath and deform the cell...
ORGANISM(S): Leptospira interrogans serovar Manilae 
2026-07-14 | PXD077813 | Pride
Cryoem Bottom up Flagella Leptospira Lc-ms/ms 
ProteomicsCore-dependent sheath architecture dictates Leptospira endoflagellar curvature
Spirochete bacteria include some of the most invasive human pathogens, causing diseases such as syphilis, Lyme disease, and leptospirosis that collectively affect millions of people annually. Their unique ability to penetrate tissues and cross biological barriers depends on periplasmic flagellar fil...
ORGANISM(S): Leptospira biflexa 
2026-07-14 | PXD073467 | Pride
Structural biology Xl-ms Leptospira endoflagellum 
ProteomicsIdentification of factors involved in the adaptation to superoxide stress in pathogenic Leptospira
Pathogenic leptospires are responsible for the zoonotic disease leptospirosis. The clinical manifestations of this infection range from a febrile state to a severe life-threatening form characterized by multiple organ hemorrhages. More than one million cases of leptospirosis are currently reported a...
ORGANISM(S): Leptospira interrogans serovar Manilae 
2025-07-10 | PXD055480 | Pride
Leptospira Superoxide Oxidative stress Spirochetes Lc-ms/ms 
ProteomicsChanges in OMPs of Leptospira under simulated physiological conditions of infection
Leptospirosis is a worldwide zoonotic disease caused bypathogenic Leptospiraspread through urine of infected animals. There are many gaps in understanding the pathophysiology of leptospirosis and the host immunity.This lack of knowledge hinders taking necessary steps in the development of a potentia...
ORGANISM(S): Leptospira interrogans serovar Icterohaemorrhagiae 
2025-09-08 | PXD035782 | Pride
Proteomics Pathogenic Leptospira 
ProteomicsOuter membrane proteome of Leptospira; revealing the bottom of iceberg
Leptospira, the causative agent of leptospirosis is known to have several proteases with potential to degrade extracellular matrix. However, a multipronged approach to identify, classify, characterize and elucidate their role has not been attempted. In this study, we carried out in-depth proteomic a...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2020-09-01 | PXD016204 | Pride
Pathogenic high resolution proteomics Protease Pathogenesis Outer membrane Leptospira 
ProteomicsProteomic approach and expression analysis revealed the differential expression of leptospiral proteases capable of ECM degradation
Leptospira, the causative agent of leptospirosis is known to have several proteases with potential to degrade extracellular matrix. However, a multipronged approach to identify, classify, characterize and elucidate their role has not been attempted. In this study, we carried out in-depth proteomic a...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2018-04-18 | PXD009050 | Pride
High resolution proteomics Protease Pathogenesis Leptospira Metalloprotease 
ProteomicsBiomarkers for canine Leptospira vaccine potency
Mandatory potency testing of Leptospira vaccine batches relies partially on in vivo procedures, requiring large numbers of laboratory animals. Cell-based assays could replace in vivo tests if biomarkers indicative of Leptospira vaccine potency are identified. We investigated innate immune responsive...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2022-03-06 | PXD031875 | Pride
Innate immunity Vaccine Monocyte Dog Biomarker Leptospira 
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