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ProteomicsEPIGENETIC MODULATION IN LIVE CELLS USING A PEPTIDE OF THE C-TERMINAL UNSTRUCTURED TAIL OF H2A.Z
H2A.Z-nucleosomes participate in both euchromatic and heterochromatic scenarios and it has proven difficult to reveal correlation of the disparate roles with the stability features imparted by H2A.Z on the nucleosomes. Using a robust in situ assay of nucleosome stability and cell lines expressing on...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD040998 | Pride
Histone Nucleosome stability Epigenetics 
ProteomicsSolubility based mechanistic profiling of combinatorial drug therapy
Acute myeloid leukemia (AML) poses a major clinical challenge due to its genetic diversity, relapse rates, and chemotherapy toxicity. While rational drug combinations improve efficacy, their mechanisms remain poorly understood. We introduce CoPISA (Proteome Integral Solubility/Stability Alteration A...
ORGANISM(S): Homo sapiens (Human) 
2026-02-12 | PXD066812 | Pride
Combination therapy Acute myeloid leukaemia Proteome integral solubility alteration assay for combinations Copisa 
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