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ProteomicsComprehensive spectral library generation for identification and quantification of endometrial cancer protein biomarkers in cervico-vaginal fluid
This study focuses on the potential of detecting endometrial cancer based on the proteins and peptides expressed in cervico-vaginal fluid.Sequential window acquisition of all theoretical mass spectra (SWATH-MS), an accurate and reproducible platform for analysing biological samples, offers a technol...
ORGANISM(S): Homo sapiens (Human) 
2021-08-13 | PXD025925 | Pride
Endemetrial cancer Proteomics Spectral library Biomarkers Cervico-vaginal fluid 
MetabolomicsIntegrated Multi-Omics Analysis Reveals the Impact of Vaginal Microbiota on the Microenvironment During Cervical Precancerous Progression

In this study, 172 HPV-positive patients were enrolled, of which 103 were diagnosed with low-grade squamous intraepithelial lesion (LSIL) and 69 with high-grade squamous intraepithelial lesion (HSIL). Vaginal secretions from 90 (60 with HSIL and 30 with LSIL) of these patients were collected in 8...

2025-09-19 | MTBLS12636 | MetaboLights
UnknownMeasurement of tissue azithromycin levels in self-collected vaginal swabs post treatment using liquid chromatography and tandem mass spectrometry (LC-MS/MS).
Not available
S-EPMC5428968 | biostudies-literature
MetabolomicsDirect on-swab metabolic profiling of vaginal microbiome:host interactions during pregnancy and preterm birth

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of...

2021-09-23 | MTBLS717 | MetaboLights
ProteomicsDried human cervico vagnial fluid on FTA-cards LC-MS/MS
Cervical cancer is the fourth most common cancer among women worldwide and screening pro-grams increase detection rate and survivability. Molecular screening of presence of human papil-loma viruses (HPV) as alternatives to physical examinations offers cost-efficient solutions and can be performed on...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026064 | Pride
Cvf Cerivcal cancer Fta-card Lc-ms/ms 
MetabolomicsPreterm birth is associated with xenobiotics and predicted by the vaginal metabolome
Spontaneous preterm birth (sPTB) is a leading cause of maternal and neonatal morbidity and mortality, yet its prevention and early risk stratification are limited. Previous investigations have suggested that vaginal microbes and metabolites may be implicated in sPTB. Here we performed untargeted met...
2022-11-21 | MTBLS702 | MetaboLights
UnknownEffects of letrozole on serum estradiol and estrone in postmenopausal breast cancer patients and tolerability of treatment: a prospective trial using a highly sensitive LC-MS/MS (liquid chromatography-tandem mass spectrometry) method for estrogen measurement.
Not available
S-EPMC10460747 | biostudies-literature
UnknownDual quantification of dapivirine and maraviroc in cervicovaginal secretions from ophthalmic tear strips and polyester-based swabs via liquid chromatographic-tandem mass spectrometric (LC-MS/MS) analysis.
Not available
S-EPMC4143664 | biostudies-literature
UnknownIdentification of Candidate Protein Biomarkers for CIN2+ Lesions from Self-Sampled, Dried Cervico-Vaginal Fluid Using LC-MS/MS.
Not available
S-EPMC8198222 | biostudies-literature
ProteomicsVaginal secretory proteome dynamically changes across the early and mid-trimesters of pregnancy
This study investigates the dynamic alterations in high vaginal fluid (HVF) proteome and its correlation with physiological changes during progression of term pregnancy. The HVF samples were collected at three time points as defined as V1 (6-12 weeks), V2 (18-20 weeks) and V3 (26-28 weeks) and SWAT...
ORGANISM(S): Homo sapiens (Human) 
2021-01-28 | PXD021811 | Pride
Pregnancy Human vaginal fluid Longitudinal study Mrm Swath ms 
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