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ProteomicsDepletion of Keratin8 affects tumorigenic potential of A431 cells via altering multiple signaling pathways
Keratins are the largest subgroup of intermediate filament proteins which are expressed in a tissue specific and differentiation state dependent manner. Apart from their mechanical functions, they have been shown to perform various regulatory roles. Most of these functions have been studied on ker...
ORGANISM(S): Homo sapiens (Human) 
2018-02-27 | PXD007206 | Pride
Human Quantitative proteomics Tmt Skin-scc Keratin 8 
ProteomicsQuantitative phosphoproteomic analysis reveals system-wide signaling pathways regulated by site-specific phosphorylation on Keratin-8 in skin squamous cell carcinoma derived cell-line
The epithelial specific keratin pair, Keratin 8/18 (K8/18), has been reported to be aberrantly expressed in squamous cell carcinoma (SCC) which is also correlated with increased invasiveness and poor prognosis. A Majority of Keratin 8 (K8) functions are governed by its phosphorylation at Serine73 (...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD005301 | Pride
Keratin 8 phosphorylation Tmt based quantitative phosphoproteomics Human epidermoid carcinoma cell-line 
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