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TranscriptomicsQS wild type and Aldh1a1-/- preadipocytes 2015
The goal of this study was to identify preadipocyte signature genes that are dependent in aldehyde dehydrogenase 1a1 (Aldh1a1) by comparison genomes of the immortalized wild type and Aldh1a1-/- preadipocytes. Gene expression was measured using theAffymetrix GeneChip Mouse Gene ST 2.0 arrays. Murine ...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-69573 | biostudies-arrayexpress
UnknownCombination of the mTOR inhibitor ridaforolimus and the anti-IGF1R monoclonal antibody dalotuzumab: preclinical characterization and phase I clinical trial.
Not available
S-EPMC5705197 | biostudies-literature
TranscriptomicsTranscriptome analysis of Arabidopsis thaliana G protein subunit mutants in response to abscisic acid (ABA)
Heterotrimeric G proteins mediate crucial and diverse signaling pathways in eukaryotes. To gain insights into the regulatory modes of the G protein and the co-regulatory modes of the G protein and the stress hormone abscisic acid (ABA), we generated and analyzed gene expression in G protein subunit ...
ORGANISM(S): Arabidopsis thaliana 
2010-12-06 | E-GEOD-19520 | biostudies-arrayexpress
TranscriptomicsRole of the prophages in the Staphylococcus aureus pathogenesis
Staphylococcus aureus is a Gram-positive human pathogen causing a variety of human diseases in both hospital and community settings. This bacterium is so closely associated with prophages that it is rare to find S. aureus isolates without prophages. Two phages are known to be important for staphyloc...
ORGANISM(S): Staphylococcus aureus 
2011-02-28 | E-GEOD-26623 | biostudies-arrayexpress
UnknownSafety overview and management of inavolisib alone and in combination therapies in PIK3CA-mutated, HR-positive, HER2-negative advanced breast cancer (GO39374).
Not available
S-EPMC12205636 | biostudies-literature
TranscriptomicsTissue Slice Grafts of Human Renal Cell Carcinoma: an Authentic Preclinical Model with High Engraftment Rate and Metastatic Potential
Purpose: Discovery of curative therapies for renal cell carcinoma (RCC) is hampered by lack of authentic preclinical models. Tumorgrafts, generated by direct implantation of patient-derived tissues into mice, have demonstrated superior ability to predict therapeutic response. We evaluated “tissu...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-44548 | biostudies-arrayexpress
TranscriptomicsA Patient-derived In Vitro - In Vivo Preclinical Model of Renal Cell Carcinoma
Purpose: Authentic preclinical models of renal cell carcinoma (RCC) are lacking. We aimed to establish and characterize primary RCC cultures and demonstrate the feasibility of evaluating drug responses in vitro and in vivo. Materials and Methods: Previously published methodology, with minor modific...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-47356 | biostudies-arrayexpress
TranscriptomicsExpression of lignin-degrading enzymes in soils using targeted microarrays
Microarrays have become established tools for describing microbial systems, however the assessment of expression profiles for environmental microbial communities still presents unique challenges. Notably, the concentration of particular transcripts are likely very dilute relative to the pool of tot...
ORGANISM(S): Phanerochaete chrysosporium 
2010-05-18 | E-GEOD-13977 | biostudies-arrayexpress
UnknownLandscape of Baseline and Acquired Genomic Alterations in Circulating Tumor DNA with Abemaciclib Alone or with Endocrine Therapy in Advanced Breast Cancer.
Not available
S-EPMC11094424 | biostudies-literature
UnknownSafety and efficacy of tiragolumab, atezolizumab and chemotherapy for early-stage or PD-L1-positive advanced triple-negative breast cancer: a phase Ib study.
Not available
S-EPMC12689193 | biostudies-literature
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